Arginine dimethylation products in pediatric patients with chronic kidney disease

Abstract Background arginine and its metabolites have been linked to pediatric chronic kidney disease (CKD). We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney fun...

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Published in:Annals of medicine and surgery 2016-08, Vol.9, p.22-27
Main Authors: El-Sadek, Akram E, Behery, Eman G, Azab, Ahmed A, Kamal, Naglaa M, Salama, Mostafa A, Abdulghany, Waleed E, Abdallah, Enas A.A
Format: Article
Language:English
Subjects:
Chronic kidney disease
Internal Medicine
Kidney functions
Original Research
Serum arginine
Serum dimethyl arginine derivatives
Surgery
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container_title Annals of medicine and surgery
container_volume 9
creator El-Sadek, Akram E
Behery, Eman G
Azab, Ahmed A
Kamal, Naglaa M
Salama, Mostafa A
Abdulghany, Waleed E
Abdallah, Enas A.A
description Abstract Background arginine and its metabolites have been linked to pediatric chronic kidney disease (CKD). We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney function. Patients and methods 132 pediatric patients with CKD and 120 healthy age and sex matched controls were compared regarding; serum Arg, ADMA and SDMA levels. Results In comparison to their values in control subjects, serum Arg levels were significantly lower; serum ADMA levels were non-significantly higher, but serum SDMA levels were significantly higher in CKD patients (p values: < 0.000; = 0.054;
doi_str_mv 10.1016/j.amsu.2016.05.017
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We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney function. Patients and methods 132 pediatric patients with CKD and 120 healthy age and sex matched controls were compared regarding; serum Arg, ADMA and SDMA levels. Results In comparison to their values in control subjects, serum Arg levels were significantly lower; serum ADMA levels were non-significantly higher, but serum SDMA levels were significantly higher in CKD patients (p values: &lt; 0.000; = 0.054; &lt;0.000, respectively). Calculated Arg/ADMA and Arg/SDMA ratios were significantly higher in patients compared to controls (p values: 0.001, and &lt;0.000, respectively). However ADMA/SDMA ratio was significantly lower in patients compared to controls (p = 0.001. Serum Arg levels showed positive significant correlation, while serum ADMA and SDMA levels showed negative significant correlation with eGFR. Moreover, Arg/ADMA ratio showed negative significant correlation, while ADMA/SDMA ratio showed positive significant correlation with eGFR of patients. Regression analysis defined high serum SDMA level as persistently significant predictor for low eGFR. Conclusion Disturbed serum levels of arginine and its dimethyl derivatives may underlie development and/or progression of CKD. Elevated serum SDMA level is strongly correlated with impaired kidney functions and could be considered as a predictor for kidney functions deterioration and CKD progression.</description><identifier>ISSN: 2049-0801</identifier><identifier>EISSN: 2049-0801</identifier><identifier>DOI: 10.1016/j.amsu.2016.05.017</identifier><identifier>PMID: 27358729</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Chronic kidney disease ; Internal Medicine ; Kidney functions ; Original Research ; Serum arginine ; Serum dimethyl arginine derivatives ; Surgery</subject><ispartof>Annals of medicine and surgery, 2016-08, Vol.9, p.22-27</ispartof><rights>The Authors</rights><rights>2016 The Authors</rights><rights>2016 The Authors 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-a6cd081c437146f27a6b5cb7fc519b12e41118786d3245bd46458247094ff6693</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915955/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2049080116300619$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27358729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Sadek, Akram E</creatorcontrib><creatorcontrib>Behery, Eman G</creatorcontrib><creatorcontrib>Azab, Ahmed A</creatorcontrib><creatorcontrib>Kamal, Naglaa M</creatorcontrib><creatorcontrib>Salama, Mostafa A</creatorcontrib><creatorcontrib>Abdulghany, Waleed E</creatorcontrib><creatorcontrib>Abdallah, Enas A.A</creatorcontrib><title>Arginine dimethylation products in pediatric patients with chronic kidney disease</title><title>Annals of medicine and surgery</title><addtitle>Ann Med Surg (Lond)</addtitle><description>Abstract Background arginine and its metabolites have been linked to pediatric chronic kidney disease (CKD). We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney function. Patients and methods 132 pediatric patients with CKD and 120 healthy age and sex matched controls were compared regarding; serum Arg, ADMA and SDMA levels. Results In comparison to their values in control subjects, serum Arg levels were significantly lower; serum ADMA levels were non-significantly higher, but serum SDMA levels were significantly higher in CKD patients (p values: &lt; 0.000; = 0.054; &lt;0.000, respectively). Calculated Arg/ADMA and Arg/SDMA ratios were significantly higher in patients compared to controls (p values: 0.001, and &lt;0.000, respectively). However ADMA/SDMA ratio was significantly lower in patients compared to controls (p = 0.001. Serum Arg levels showed positive significant correlation, while serum ADMA and SDMA levels showed negative significant correlation with eGFR. Moreover, Arg/ADMA ratio showed negative significant correlation, while ADMA/SDMA ratio showed positive significant correlation with eGFR of patients. Regression analysis defined high serum SDMA level as persistently significant predictor for low eGFR. Conclusion Disturbed serum levels of arginine and its dimethyl derivatives may underlie development and/or progression of CKD. Elevated serum SDMA level is strongly correlated with impaired kidney functions and could be considered as a predictor for kidney functions deterioration and CKD progression.</description><subject>Chronic kidney disease</subject><subject>Internal Medicine</subject><subject>Kidney functions</subject><subject>Original Research</subject><subject>Serum arginine</subject><subject>Serum dimethyl arginine derivatives</subject><subject>Surgery</subject><issn>2049-0801</issn><issn>2049-0801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9Uk1r3DAQNaWlCWn-QA_Fx17WnZEl2YYSCCH9gEApbc-DLI-z2tjWVrJT9t9XZtOQ9tCThnlvnob3JsteIxQIqN_tCjPGpRCpLkAVgNWz7FSAbDZQAz5_Up9k5zHuAABBlVrXL7MTUZWqrkRzmn29DLduchPnnRt53h4GMzs_5fvgu8XOMXep5s6ZOTib7xPIU-r-cvM2t9vgp9S9c93EhyQQ2UR-lb3ozRD5_OE9y358uP5-9Wlz8-Xj56vLm41VCPPGaNtBjVaWFUrdi8roVtm26hPctChYImJd1borhVRtJ7VUtZAVNLLvtW7Ks-ziqLtf2pE7m_YKZqB9cKMJB_LG0d_I5LZ06-9JNqgapZLA2weB4H8uHGcaXbQ8DGZiv0TC5J0sRa11oooj1QYfY-D-8RsEWuOgHa1x0BoHgaIURxp683TBx5E_5ifC-yOBk033jgNFm-y1ye7AdqbOu__rX_wzbocUpTXDHR847vwSphQAIUVBQN_Wg1jvAXUJoLEpfwNN4rGT</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>El-Sadek, Akram E</creator><creator>Behery, Eman G</creator><creator>Azab, Ahmed A</creator><creator>Kamal, Naglaa M</creator><creator>Salama, Mostafa A</creator><creator>Abdulghany, Waleed E</creator><creator>Abdallah, Enas A.A</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160801</creationdate><title>Arginine dimethylation products in pediatric patients with chronic kidney disease</title><author>El-Sadek, Akram E ; Behery, Eman G ; Azab, Ahmed A ; Kamal, Naglaa M ; Salama, Mostafa A ; Abdulghany, Waleed E ; Abdallah, Enas A.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-a6cd081c437146f27a6b5cb7fc519b12e41118786d3245bd46458247094ff6693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Chronic kidney disease</topic><topic>Internal Medicine</topic><topic>Kidney functions</topic><topic>Original Research</topic><topic>Serum arginine</topic><topic>Serum dimethyl arginine derivatives</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Sadek, Akram E</creatorcontrib><creatorcontrib>Behery, Eman G</creatorcontrib><creatorcontrib>Azab, Ahmed A</creatorcontrib><creatorcontrib>Kamal, Naglaa M</creatorcontrib><creatorcontrib>Salama, Mostafa A</creatorcontrib><creatorcontrib>Abdulghany, Waleed E</creatorcontrib><creatorcontrib>Abdallah, Enas A.A</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Sadek, Akram E</au><au>Behery, Eman G</au><au>Azab, Ahmed A</au><au>Kamal, Naglaa M</au><au>Salama, Mostafa A</au><au>Abdulghany, Waleed E</au><au>Abdallah, Enas A.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arginine dimethylation products in pediatric patients with chronic kidney disease</atitle><jtitle>Annals of medicine and surgery</jtitle><addtitle>Ann Med Surg (Lond)</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>9</volume><spage>22</spage><epage>27</epage><pages>22-27</pages><issn>2049-0801</issn><eissn>2049-0801</eissn><abstract>Abstract Background arginine and its metabolites have been linked to pediatric chronic kidney disease (CKD). We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney function. Patients and methods 132 pediatric patients with CKD and 120 healthy age and sex matched controls were compared regarding; serum Arg, ADMA and SDMA levels. Results In comparison to their values in control subjects, serum Arg levels were significantly lower; serum ADMA levels were non-significantly higher, but serum SDMA levels were significantly higher in CKD patients (p values: &lt; 0.000; = 0.054; &lt;0.000, respectively). Calculated Arg/ADMA and Arg/SDMA ratios were significantly higher in patients compared to controls (p values: 0.001, and &lt;0.000, respectively). However ADMA/SDMA ratio was significantly lower in patients compared to controls (p = 0.001. Serum Arg levels showed positive significant correlation, while serum ADMA and SDMA levels showed negative significant correlation with eGFR. Moreover, Arg/ADMA ratio showed negative significant correlation, while ADMA/SDMA ratio showed positive significant correlation with eGFR of patients. Regression analysis defined high serum SDMA level as persistently significant predictor for low eGFR. Conclusion Disturbed serum levels of arginine and its dimethyl derivatives may underlie development and/or progression of CKD. Elevated serum SDMA level is strongly correlated with impaired kidney functions and could be considered as a predictor for kidney functions deterioration and CKD progression.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27358729</pmid><doi>10.1016/j.amsu.2016.05.017</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Chronic kidney disease
Internal Medicine
Kidney functions
Original Research
Serum arginine
Serum dimethyl arginine derivatives
Surgery
title Arginine dimethylation products in pediatric patients with chronic kidney disease
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