Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF/ICSI-ET

Growth differentiation factor-8 (GDF-8) is found in the human serum, follicular fluid and granulosa cells. Our previous studies have shown that the human cumulus expansion and steroidogenesis can be regulated by GDF-8. However, thus far, the expression profile of GDF-8 in serum and whether the level...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.28036-28036, Article 28036
Main Authors: Fang, Lanlan, Yu, Yiping, Zhang, Ruizhe, He, Jingyan, Sun, Ying-Pu
Format: Article
Language:English
Subjects:
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Adult
Area Under Curve
Chorionic Gonadotropin - administration & dosage
Embryo Transfer
Endometrium
Enzyme-Linked Immunosorbent Assay
Female
Fertilization in Vitro
Follicular Fluid - metabolism
Humanities and Social Sciences
Humans
In vitro fertilization
multidisciplinary
Myostatin - blood
Ovaries
Ovulation Induction
Pregnancy
Pregnancy Rate
Prospective Studies
Reproductive system
ROC Curve
Science
Sperm Injections, Intracytoplasmic
Triptorelin Pamoate - administration & dosage
Young Adult
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Summary:Growth differentiation factor-8 (GDF-8) is found in the human serum, follicular fluid and granulosa cells. Our previous studies have shown that the human cumulus expansion and steroidogenesis can be regulated by GDF-8. However, thus far, the expression profile of GDF-8 in serum and whether the level of serum GDF-8 influences pregnancy results for patients treated with in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) is totally unknown. In this study, we showed that GDF-8 had a dynamic trend during controlled ovarian hyperstimulation (COH) procedure. On human chorionic gonadotropin (hCG) administration day, patients with a GDF-8 level higher than 4.7 ng/ml had lower progesterone levels and a higher pregnancy rate. From hCG day to oocyte pick-up day, patients with a GDF-8 decrease greater than 1.3 ng/ml had a higher progesterone increase and a higher pregnancy rate. Importantly, the levels of GDF-8 were negatively correlated with progesterone levels. Our findings provide evidences that GDF-8 plays an important role in ensuring successful pregnancy by regulating progesterone levels.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep28036