Orosomucoid-1 Expression in Ameloblastoma Variants

• Published in: International journal of molecular and cellular medicine 2016, Vol.5 (1), p.49-56
• Main Authors: García-Muñoz, Alejandro, Bologna-Molina, Ronell, A Rodríguez, Mario, Liceága-Reyes, Rodrigo, Farfán-Morales, Jose Eduardo, Aranda-Romo, Saray, Molina-Frechero, Nelly, González-González, Rogelio
• Format: Article
• Language: English
• Subjects: Short Communication
• ISSN: 2251-9637; 2251-9645

Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.