Strength through Diversity

The remarkable versatility of the mammalian brain is made possible by a huge diversity of cellular plasticity mechanisms. These include long-term potentiation and depression at both excitatory and inhibitory synapses, as well as a variety of intrinsic and homeostatic plasticity mechanisms. A fundame...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2008-11, Vol.60 (3), p.477-482
Main Authors: Nelson, Sacha B., Turrigiano, Gina G.
Format: Article
Language:English
Subjects:
Animals
Behavior
Behavior - physiology
Cerebral Cortex - anatomy & histology
Cerebral Cortex - physiology
Hippocampus - anatomy & histology
Hippocampus - physiology
Homeostasis - physiology
Kinases
Long-Term Potentiation - physiology
Long-Term Synaptic Depression - physiology
Nerve Net - anatomy & histology
Nerve Net - physiology
Neuronal Plasticity - physiology
Neurons
Studies
Synapses - physiology
Synaptic Transmission - physiology
Tetanus
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Summary:The remarkable versatility of the mammalian brain is made possible by a huge diversity of cellular plasticity mechanisms. These include long-term potentiation and depression at both excitatory and inhibitory synapses, as well as a variety of intrinsic and homeostatic plasticity mechanisms. A fundamental challenge for the field is to assemble our detailed knowledge of these specific mechanisms into a coherent picture of how plasticity within cortical circuits works to tune network properties.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2008.10.020