Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it’s hypothesized that gastrointestinal microbiota might play an...

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Bibliographic Details
Published in:Scientific reports 2016-06, Vol.6 (1), p.28484-28484, Article 28484
Main Authors: Chen, Jun, Chia, Nicholas, Kalari, Krishna R., Yao, Janet Z., Novotna, Martina, Paz Soldan, M. Mateo, Luckey, David H., Marietta, Eric V., Jeraldo, Patricio R., Chen, Xianfeng, Weinshenker, Brian G., Rodriguez, Moses, Kantarci, Orhun H., Nelson, Heidi, Murray, Joseph A., Mangalam, Ashutosh K.
Format: Article
Language:English
Subjects:
45/22
45/23
45/77
631/326/2565/2134
692/699/375/1666
Adult
Autoimmune diseases
Disease
Dysbiosis - microbiology
Environmental factors
Feces
Female
Gastrointestinal Microbiome - genetics
Gastrointestinal Tract - microbiology
Humanities and Social Sciences
Humans
Hypotheses
Male
Microbiota
Microbiota - genetics
multidisciplinary
Multiple sclerosis
Multiple Sclerosis - microbiology
Remission (Medicine)
RNA, Ribosomal, 16S - genetics
Science
Science (multidisciplinary)
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Summary:Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it’s hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3–V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia , and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep28484