Congenital myasthenia gravis: clinical and HLA studies in two brothers

Two brothers with congenital myasthenia gravis are described. In both, ptosis and ophthalmoplegia responded poorly to oral anticholinesterase therapy and to thymectomy. The brothers had two different HLA haplotypes and neither had the HLA-A1-B8-DW3 haplotypes which are commonly associated with myath...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1976-12, Vol.39 (12), p.1145-1150
Main Authors: Whiteley, A M, Schwartz, M S, Sachs, J A, Swash, M
Format: Article
Language:English
Subjects:
Adult
Blepharoptosis
Histocompatibility Antigens - analysis
HLA Antigens - analysis
Humans
Male
Myasthenia Gravis - congenital
Myasthenia Gravis - genetics
Myasthenia Gravis - therapy
Ophthalmoplegia
Pyridostigmine Bromide - therapeutic use
Thymectomy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two brothers with congenital myasthenia gravis are described. In both, ptosis and ophthalmoplegia responded poorly to oral anticholinesterase therapy and to thymectomy. The brothers had two different HLA haplotypes and neither had the HLA-A1-B8-DW3 haplotypes which are commonly associated with myathenia gravis in adult-onset cases.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.39.12.1145