Applications of Fourier Transform Ion Cyclotron Resonance (FT-ICR) and Orbitrap Based High Resolution Mass Spectrometry in Metabolomics and Lipidomics

Metabolomics, along with other "omics" approaches, is rapidly becoming one of the major approaches aimed at understanding the organization and dynamics of metabolic networks. Mass spectrometry is often a technique of choice for metabolomics studies due to its high sensitivity, reproducibil...

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Bibliographic Details
Published in:International journal of molecular sciences 2016-06, Vol.17 (6), p.816-816
Main Authors: Ghaste, Manoj, Mistrik, Robert, Shulaev, Vladimir
Format: Article
Language:English
Subjects:
Cyclotrons
Data analysis
Fourier Analysis
Lipid Metabolism
Mass spectrometry
Mass Spectrometry - methods
Metabolism
Metabolomics - methods
Review
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Summary:Metabolomics, along with other "omics" approaches, is rapidly becoming one of the major approaches aimed at understanding the organization and dynamics of metabolic networks. Mass spectrometry is often a technique of choice for metabolomics studies due to its high sensitivity, reproducibility and wide dynamic range. High resolution mass spectrometry (HRMS) is a widely practiced technique in analytical and bioanalytical sciences. It offers exceptionally high resolution and the highest degree of structural confirmation. Many metabolomics studies have been conducted using HRMS over the past decade. In this review, we will explore the latest developments in Fourier transform mass spectrometry (FTMS) and Orbitrap based metabolomics technology, its advantages and drawbacks for using in metabolomics and lipidomics studies, and development of novel approaches for processing HRMS data.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17060816