The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3

Adrenal glands are zonated endocrine organs that are essential in controlling body homeostasis. How zonation is induced and maintained and how renewal of the adrenal cortex is ensured remain a mystery. Here we show that capsular RSPO3 signals to the underlying steroidogenic compartment to induce β-c...

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Bibliographic Details
Published in:Genes & development 2016-06, Vol.30 (12), p.1389-1394
Main Authors: Vidal, Valerie, Sacco, Sonia, Rocha, Ana Sofia, da Silva, Fabio, Panzolini, Clara, Dumontet, Typhanie, Doan, Thi Mai Phuong, Shan, Jingdong, Rak-Raszewska, Aleksandra, Bird, Tom, Vainio, Seppo, Martinez, Antoine, Schedl, Andreas
Format: Article
Language:English
Subjects:
Adrenal Cortex - cytology
Adrenal Cortex - physiology
Animal genetics
Animals
beta Catenin - metabolism
Biochemistry, Molecular Biology
Cancer
Cell Differentiation - genetics
Cell Proliferation
Development Biology
Embryo, Mammalian
Embryology and Organogenesis
Endocrinology and metabolism
Gene Deletion
Gene Expression Regulation, Developmental - genetics
Genetics
Genomics
Homeostasis - genetics
Human health and pathology
Life Sciences
Male
Mice
Molecular biology
Research Communication
Signal Transduction - genetics
Thrombospondins - genetics
Thrombospondins - metabolism
Zona Glomerulosa - cytology
Zona Glomerulosa - metabolism
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Summary:Adrenal glands are zonated endocrine organs that are essential in controlling body homeostasis. How zonation is induced and maintained and how renewal of the adrenal cortex is ensured remain a mystery. Here we show that capsular RSPO3 signals to the underlying steroidogenic compartment to induce β-catenin signaling and imprint glomerulosa cell fate. Deletion of RSPO3 leads to loss of SHH signaling and impaired organ growth. Importantly, Rspo3 function remains essential in adult life to ensure replenishment of lost cells and maintain the properties of the zona glomerulosa. Thus, the adrenal capsule acts as a central signaling center that ensures replacement of damaged cells and is required to maintain zonation throughout life.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.277756.116