Complexities of Gut Microbiome Dysbiosis in the Context of HIV Infection and Antiretroviral Therapy

Human immunodeficiency virus (HIV) infection is associated with an altered gut microbiome that is not consistently restored with effective antiretroviral therapy (ART). Interpretation of the specific microbiome changes observed during HIV infection is complicated by factors like population, sample t...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2016-06, Vol.99 (6), p.600-611
Main Authors: Li, SX, Armstrong, AJS, Neff, CP, Shaffer, M, Lozupone, CA, Palmer, BE
Format: Article
Language:English
Subjects:
Animals
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active - adverse effects
Antiretroviral Therapy, Highly Active - methods
Dysbiosis - immunology
Dysbiosis - microbiology
Gastrointestinal Microbiome
HIV Infections - drug therapy
HIV Infections - microbiology
Humans
Microbiota
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Summary:Human immunodeficiency virus (HIV) infection is associated with an altered gut microbiome that is not consistently restored with effective antiretroviral therapy (ART). Interpretation of the specific microbiome changes observed during HIV infection is complicated by factors like population, sample type, and ART—each of which may have dramatic effects on gut bacteria. Understanding how these factors shape the microbiome during HIV infection (which we refer to as the HIV‐associated microbiome) is critical for defining its role in HIV disease, and for developing therapies that restore gut health during infection.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.363