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Complexities of Gut Microbiome Dysbiosis in the Context of HIV Infection and Antiretroviral Therapy
Human immunodeficiency virus (HIV) infection is associated with an altered gut microbiome that is not consistently restored with effective antiretroviral therapy (ART). Interpretation of the specific microbiome changes observed during HIV infection is complicated by factors like population, sample t...
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| Published in: | Clinical pharmacology and therapeutics 2016-06, Vol.99 (6), p.600-611 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4433-a543e724f18305da09b45e227b1aff26d9a04a524015d4235f637aef262e2e813 |
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| cites | cdi_FETCH-LOGICAL-c4433-a543e724f18305da09b45e227b1aff26d9a04a524015d4235f637aef262e2e813 |
| container_end_page | 611 |
| container_issue | 6 |
| container_start_page | 600 |
| container_title | Clinical pharmacology and therapeutics |
| container_volume | 99 |
| creator | Li, SX Armstrong, AJS Neff, CP Shaffer, M Lozupone, CA Palmer, BE |
| description | Human immunodeficiency virus (HIV) infection is associated with an altered gut microbiome that is not consistently restored with effective antiretroviral therapy (ART). Interpretation of the specific microbiome changes observed during HIV infection is complicated by factors like population, sample type, and ART—each of which may have dramatic effects on gut bacteria. Understanding how these factors shape the microbiome during HIV infection (which we refer to as the HIV‐associated microbiome) is critical for defining its role in HIV disease, and for developing therapies that restore gut health during infection. |
| doi_str_mv | 10.1002/cpt.363 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0009-9236 |
| ispartof | Clinical pharmacology and therapeutics, 2016-06, Vol.99 (6), p.600-611 |
| issn | 0009-9236 1532-6535 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4927263 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active - adverse effects Antiretroviral Therapy, Highly Active - methods Dysbiosis - immunology Dysbiosis - microbiology Gastrointestinal Microbiome HIV Infections - drug therapy HIV Infections - microbiology Humans Microbiota |
| title | Complexities of Gut Microbiome Dysbiosis in the Context of HIV Infection and Antiretroviral Therapy |
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