Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection

Natural killer (NK) cell is an important component in innate immunity, playing a critical role in bridging innate and adaptive immunity by modulating the function of other immune cells including T cells. In this study, we focused on the role of NK cells in regulating Th1/Treg and Th17/Treg balance d...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2016-07, Vol.20 (7), p.1339-1351
Main Authors: Li, Jing, Dong, Xiaojing, Zhao, Lei, Wang, Xiao, Wang, Yan, Yang, Xi, Wang, Hong, Zhao, Weiming
Format: Article
Language:English
Subjects:
Adaptive immunity
Animals
Antigens, CD - metabolism
Cell number
Chlamydia
Chlamydia Infections - immunology
Cytokines
Cytokines - metabolism
Depletion
Experiments
Foxp3 protein
Helper cells
Histology
Histopathology
Immunity
immunoregulation
Infections
Innate immunity
Interferon
Killer Cells, Natural - immunology
Laboratory animals
Lung Diseases - immunology
Lung Diseases - microbiology
Lungs
Lymphatic system
Lymphocytes
Lymphocytes T
Male
Mice
Mice, Inbred BALB C
Natural killer cells
Original
Pathology
Spleen
Studies
T-Lymphocytes, Regulatory - immunology
Th1 Cells - immunology
Th1/Treg
Th17 Cells - immunology
Th17/Treg
Transcription Factors - metabolism
Transforming Growth Factor beta - metabolism
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Summary:Natural killer (NK) cell is an important component in innate immunity, playing a critical role in bridging innate and adaptive immunity by modulating the function of other immune cells including T cells. In this study, we focused on the role of NK cells in regulating Th1/Treg and Th17/Treg balance during chlamydial lung infection. We found that NK cell‐depleted mice showed decreased Th1 and Th17 cells, which was correlated with reduced interferon‐γ, interleukin (IL)‐12, IL‐17 and IL‐22 production as well as T‐bet and receptor‐related orphan receptor gamma t expression compared with mice treated with the isotype control antibody. In contrast, NK cell depletion significantly increased Treg in cell number and related transcription factor (Foxp3) expression. The opposite trends of changes of Th1/Th17 and Treg led to significant reduction in the Th1/Treg and Th17/Treg ratios. The data implicate that NK cells play an important role in host defence against chlamydial lung infection, mainly through maintaining Th1/Treg and Th17/Treg balance.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.12821