Low osteocalcin level is a risk factor for impaired glucose metabolism in a Chinese male population

• Published in: Journal of diabetes investigation 2016-07, Vol.7 (4), p.522-528
• Main Authors: Liang, Yaojie, Tan, Aihua, Liang, Danyan, Yang, Xiaobo, Liao, Ming, Gao, Yong, Jiang, Yonghua, Yao, Ziting, Lin, Xinggu, Lu, Zheng, Wu, Chunlei, Zhang, Shijun, Hu, Yanlin, Qin, Xue, Mo, Zengnan, Li, Hong, Zhang, Haiying
• Format: Article
• Language: English
• Subjects: Adult; Alcohol; Asian Continental Ancestry Group; Body mass index; Cardiovascular disease; Cell growth; China - epidemiology; Cigarette smoking; Correlation analysis; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Family medical history; Glucose; Glucose - metabolism; Glucose Metabolism Disorders - blood; Glucose Metabolism Disorders - epidemiology; Glucose tolerance; Glucose Tolerance Test; Homeostasis; Hospitals; Humans; Insulin; Insulin resistance; Laboratories; Male; Metabolism; Middle Aged; Mineralization; Obesity; Original; Osteocalcin; Osteocalcin - blood; Population; Population studies; Risk Factors; Smoking; Studies; Weight control
• ISSN: 2040-1116; 2040-1124
• DOI: 10.1111/jdi.12439

Aims/Introduction This study was to assess the association between serum osteocalcin level and glucose metabolism in a Chinese male population. Materials and Methods We carried out a cross‐sectional study with a cohort of participants from the Fangchenggang Area Male Health and Examination Survey. The cross‐sectional study was carried out among 2,353 men, including 2,139 participants with normal glucose tolerance, 148 with impaired fasting glucose and 66 with type 2 diabetes. A subsample of 1,109 men with measurement of osteocalcin was observed in the cohort. After a 4‐year follow‐up period, 1,049 non‐diabetic and 983 participants with normal glucose tolerance who submitted the available information were enrolled in the cohort. Participants were divided into group‐H (≥23.33 ng/mL) and group‐L (