Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia

Tinofedrine, a new derivative of l-norephedrine, was examined for cerebral vasodilator activity in man. Ten patients with reduced cerebral blood flow (CBF) and multi-infarct dementia were given the drug intravenously. Cerebral blood flow increased significantly by 28% from a mean of 43.3 to 55.5 ml/...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1978-10, Vol.41 (10), p.900-902
Main Authors: Merory, J, Du Boulay, G H, Marshall, J, Morris, J, Russell, R W, Symon, L, Thomas, D J
Format: Article
Language:English
Subjects:
Aged
Blood Pressure - drug effects
Brain - blood supply
Carbon Dioxide - blood
Cerebral Infarction - complications
Cerebral Infarction - drug therapy
Dementia
Dementia - drug therapy
Dementia - etiology
Drug Evaluation
Female
Humans
Injections, Intravenous
Male
Middle Aged
Phenylpropanolamine - analogs & derivatives
Phenylpropanolamine - therapeutic use
Regional Blood Flow - drug effects
Vasodilator Agents - administration & dosage
Vasodilator Agents - therapeutic use
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Summary:Tinofedrine, a new derivative of l-norephedrine, was examined for cerebral vasodilator activity in man. Ten patients with reduced cerebral blood flow (CBF) and multi-infarct dementia were given the drug intravenously. Cerebral blood flow increased significantly by 28% from a mean of 43.3 to 55.5 ml/100 g/min.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.41.10.900