Effect of anticonvulsants on plasma testosterone and sex hormone binding globulin levels

Plasma sex hormone binding globulin (SHBG) and testosterone levels were measured in 29 patients with epilepsy (16 men and 13 women), most of them on chronic therapy with anticonvulsant drugs. Sex hormone binding globulin concentrations were increased in both sexes and testosterone levels in male pat...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1978-10, Vol.41 (10), p.913-914
Main Authors: Barragry, J M, Makin, H L, Trafford, D J, Scott, D F
Format: Article
Language:English
Subjects:
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Carbamazepine - pharmacology
Epilepsy, Temporal Lobe - blood
Epilepsy, Temporal Lobe - drug therapy
Female
Humans
Liver - drug effects
Liver - metabolism
Male
Phenobarbital - pharmacology
Phenytoin - pharmacology
Sex Factors
Sex Hormone-Binding Globulin - analysis
Sex Hormone-Binding Globulin - metabolism
Testosterone - blood
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Summary:Plasma sex hormone binding globulin (SHBG) and testosterone levels were measured in 29 patients with epilepsy (16 men and 13 women), most of them on chronic therapy with anticonvulsant drugs. Sex hormone binding globulin concentrations were increased in both sexes and testosterone levels in male patients. It is postulated that anticonvulsants may induce hepatic synthesis of SHBG.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.41.10.913