Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study

ObjectivesTo explore potential mechanisms that underpin the cardiac abnormalities seen in chronic fatigue syndrome (CFS) using non-invasive cardiac impedance, red cell mass and plasma volume measurements.MethodsCardiac MR (MR) examinations were performed using 3 T Philips Intera Achieva scanner (Bes...

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Published in:Open heart 2016-06, Vol.3 (1), p.e000381-e000381
Main Authors: Newton, Julia L, Finkelmeyer, Andreas, Petrides, George, Frith, James, Hodgson, Tim, Maclachlan, Laura, MacGowan, Guy, Blamire, Andrew M
Format: Article
Language:English
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Special Populations
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Summary:ObjectivesTo explore potential mechanisms that underpin the cardiac abnormalities seen in chronic fatigue syndrome (CFS) using non-invasive cardiac impedance, red cell mass and plasma volume measurements.MethodsCardiac MR (MR) examinations were performed using 3 T Philips Intera Achieva scanner (Best, NL) in participants with CFS (Fukuda; n=47) and matched case-by-case controls. Total volume (TV), red cell volume (RCV) and plasma volume (PV) measurements were performed (41 CFS and 10 controls) using the indicator dilution technique using simultaneous 51-chromium labelling of red blood cells and 125-iodine labelling of serum albumin.ResultsThe CFS group length of history (mean±SD) was 14±10 years. Patients with CFS had significantly reduced end-systolic and end-diastolic volumes together with reduced end-diastolic wall masses (all p
ISSN:2053-3624
2398-595X
2053-3624
DOI:10.1136/openhrt-2015-000381