Brain aerobic glycolysis and motor adaptation learning

Ten percent to 15% of glucose used by the brain is metabolized nonoxidatively despite adequate tissue oxygenation, a process termed aerobic glycolysis (AG). Because of the known role of glycolysis in biosynthesis, we tested whether learning-induced synaptic plasticity would lead to regionally approp...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2016-06, Vol.113 (26), p.E3782-E3791
Main Authors: Shannon, Benjamin J., Vaishnavi, Sanjeev Neil, Vlassenko, Andrei G., Shimony, Joshua S., Rutlin, Jerrel, Raichle, Marcus E.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult
Aerobiosis
Alzheimer's disease
Biological Sciences
Brain - metabolism
Brain Mapping
Female
Glucose - metabolism
Glycolysis
Humans
Learning
Magnetic Resonance Imaging
Male
Memory
Motor Skills
Neuronal Plasticity
Oxidative Phosphorylation
Oxygen Consumption
PNAS Plus
Positron-Emission Tomography
Protein expression
Proteins
Toxicity
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ten percent to 15% of glucose used by the brain is metabolized nonoxidatively despite adequate tissue oxygenation, a process termed aerobic glycolysis (AG). Because of the known role of glycolysis in biosynthesis, we tested whether learning-induced synaptic plasticity would lead to regionally appropriate, learning-dependent changes in AG. Functional MRI (fMRI) before, during, and after performance of a visual–motor adaptation task demonstrated that left Brodmann area 44 (BA44) played a key role in adaptation, with learning-related changes to activity during the task and altered resting-state, functional connectivity after the task. PET scans before and after task performance indicated a sustained increase in AG in left BA 44 accompanied by decreased oxygen consumption. Intersubject variability in behavioral adaptation rate correlated strongly with changes in AG in this region, as well as functional connectivity, which is consistent with a role for AG in synaptic plasticity.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1604977113