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Prevalence of human norovirus and Clostridium difficile coinfections in adult hospitalized patients
Human norovirus (HuNoV) and Clostridium difficile are common causes of infectious gastroenteritis in adults in the US. However, limited information is available regarding HuNoV and C. difficile coinfections. Our study was designed to evaluate the prevalence of HuNoV and C. difficile coinfections amo...
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| Published in: | Clinical epidemiology 2016-01, Vol.8, p.253-260 |
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| container_title | Clinical epidemiology |
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| creator | Stokely, Janelle N Niendorf, Sandra Taube, Stefan Hoehne, Marina Young, Vincent B Rogers, Mary Am Wobus, Christiane E |
| description | Human norovirus (HuNoV) and Clostridium difficile are common causes of infectious gastroenteritis in adults in the US. However, limited information is available regarding HuNoV and C. difficile coinfections. Our study was designed to evaluate the prevalence of HuNoV and C. difficile coinfections among adult patients in a hospital setting and disease symptomatology.
For a cross-sectional analysis, 384 fecal samples were tested for the presence of C. difficile toxins from patients (n=290), whom the provider suspected of C. difficile infections. Subsequent testing was then performed for HuNoV genogroups I and II. Multinomial logistic regression was performed to determine symptoms more frequently associated with coinfections.
The final cohort consisted of the following outcome groups: C. difficile (n=196), C. difficile + HuNoV coinfection (n=40), HuNoV only (n=12), and neither (n=136). Coinfected patients were more likely to develop nausea, gas, and abdominal pain and were more likely to seek treatment in the winter season compared with individuals not infected or infected with either pathogen alone.
Our study revealed that patients with coinfection are more likely to experience certain gastrointestinal symptoms, in particular abdominal pain, suggesting an increased severity of disease symptomatology in coinfected patients. |
| doi_str_mv | 10.2147/CLEP.S106495 |
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For a cross-sectional analysis, 384 fecal samples were tested for the presence of C. difficile toxins from patients (n=290), whom the provider suspected of C. difficile infections. Subsequent testing was then performed for HuNoV genogroups I and II. Multinomial logistic regression was performed to determine symptoms more frequently associated with coinfections.
The final cohort consisted of the following outcome groups: C. difficile (n=196), C. difficile + HuNoV coinfection (n=40), HuNoV only (n=12), and neither (n=136). Coinfected patients were more likely to develop nausea, gas, and abdominal pain and were more likely to seek treatment in the winter season compared with individuals not infected or infected with either pathogen alone.
Our study revealed that patients with coinfection are more likely to experience certain gastrointestinal symptoms, in particular abdominal pain, suggesting an increased severity of disease symptomatology in coinfected patients.</description><identifier>ISSN: 1179-1349</identifier><identifier>EISSN: 1179-1349</identifier><identifier>DOI: 10.2147/CLEP.S106495</identifier><identifier>PMID: 27418856</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Abdomen ; Adults ; Age ; Anopheles ; Antibiotics ; Antigens ; Clinical medicine ; Diarrhea ; Disease control ; Epidemiology ; Gastroenteritis ; Hospital patients ; Hospitalization ; Infection ; Infections ; Infectious diseases ; Internal medicine ; Laboratories ; Medical tests ; Metronidazole ; Original Research ; Pain ; Patients ; Surveillance ; Vomiting</subject><ispartof>Clinical epidemiology, 2016-01, Vol.8, p.253-260</ispartof><rights>COPYRIGHT 2016 Dove Medical Press Limited</rights><rights>2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Stokely et al. This work is published and licensed by Dove Medical Press Limited 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-338f4f69cedb6d0c69b7ea9f02aa96aa484ac4ff9ea576bfd5a1ae57083d38c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2224438593/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2224438593?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27418856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stokely, Janelle N</creatorcontrib><creatorcontrib>Niendorf, Sandra</creatorcontrib><creatorcontrib>Taube, Stefan</creatorcontrib><creatorcontrib>Hoehne, Marina</creatorcontrib><creatorcontrib>Young, Vincent B</creatorcontrib><creatorcontrib>Rogers, Mary Am</creatorcontrib><creatorcontrib>Wobus, Christiane E</creatorcontrib><title>Prevalence of human norovirus and Clostridium difficile coinfections in adult hospitalized patients</title><title>Clinical epidemiology</title><addtitle>Clin Epidemiol</addtitle><description>Human norovirus (HuNoV) and Clostridium difficile are common causes of infectious gastroenteritis in adults in the US. However, limited information is available regarding HuNoV and C. difficile coinfections. Our study was designed to evaluate the prevalence of HuNoV and C. difficile coinfections among adult patients in a hospital setting and disease symptomatology.
For a cross-sectional analysis, 384 fecal samples were tested for the presence of C. difficile toxins from patients (n=290), whom the provider suspected of C. difficile infections. Subsequent testing was then performed for HuNoV genogroups I and II. Multinomial logistic regression was performed to determine symptoms more frequently associated with coinfections.
The final cohort consisted of the following outcome groups: C. difficile (n=196), C. difficile + HuNoV coinfection (n=40), HuNoV only (n=12), and neither (n=136). Coinfected patients were more likely to develop nausea, gas, and abdominal pain and were more likely to seek treatment in the winter season compared with individuals not infected or infected with either pathogen alone.
Our study revealed that patients with coinfection are more likely to experience certain gastrointestinal symptoms, in particular abdominal pain, suggesting an increased severity of disease symptomatology in coinfected patients.</description><subject>Abdomen</subject><subject>Adults</subject><subject>Age</subject><subject>Anopheles</subject><subject>Antibiotics</subject><subject>Antigens</subject><subject>Clinical medicine</subject><subject>Diarrhea</subject><subject>Disease control</subject><subject>Epidemiology</subject><subject>Gastroenteritis</subject><subject>Hospital patients</subject><subject>Hospitalization</subject><subject>Infection</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Internal medicine</subject><subject>Laboratories</subject><subject>Medical tests</subject><subject>Metronidazole</subject><subject>Original Research</subject><subject>Pain</subject><subject>Patients</subject><subject>Surveillance</subject><subject>Vomiting</subject><issn>1179-1349</issn><issn>1179-1349</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkd1rFDEUxQdRbGn75rMEBPGh2yaTTD5ehLLUKiy0oD6Hu_nopGSSNZlZqH-9s-5aau9LLuTHuffc0zTvCL5oCROXy9X13cV3gjlT3avmmBChFoQy9fpZf9Sc1fqA56KUCIHfNketYETKjh835q64LUSXjEPZo34aIKGUS96GMlUEyaJlzHUswYZpQDZ4H0yIDpkckndmDDlVFBICO8UR9bluwggx_HYWbWAMLo31tHnjIVZ3dnhPmp9frn8svy5WtzffllerhWGMjgtKpWeeK-PsmltsuFoLB8rjFkBxACYZGOa9ctAJvva2AwKuE1hSS6WR9KT5vNfdTOvBWTPPLhD1poQByqPOEPT_Pyn0-j5vNVOUsa6bBT4dBEr-Nbk66iFU42KE5PJUNZGYSc4I3c368AJ9yFNJsz3dtu3sR3aKztTHPXU_n1j3DuLY1xynv1fTVxy3qhVU7eTO96Apudbi_NPWBOtd0nqXtD4kPePvnzt9gv_lSv8ALPOmSQ</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Stokely, Janelle N</creator><creator>Niendorf, Sandra</creator><creator>Taube, Stefan</creator><creator>Hoehne, Marina</creator><creator>Young, Vincent B</creator><creator>Rogers, Mary Am</creator><creator>Wobus, Christiane E</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8C1</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Prevalence of human norovirus and Clostridium difficile coinfections in adult hospitalized patients</title><author>Stokely, Janelle N ; Niendorf, Sandra ; Taube, Stefan ; Hoehne, Marina ; Young, Vincent B ; Rogers, Mary Am ; Wobus, Christiane E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-338f4f69cedb6d0c69b7ea9f02aa96aa484ac4ff9ea576bfd5a1ae57083d38c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abdomen</topic><topic>Adults</topic><topic>Age</topic><topic>Anopheles</topic><topic>Antibiotics</topic><topic>Antigens</topic><topic>Clinical medicine</topic><topic>Diarrhea</topic><topic>Disease control</topic><topic>Epidemiology</topic><topic>Gastroenteritis</topic><topic>Hospital patients</topic><topic>Hospitalization</topic><topic>Infection</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Internal medicine</topic><topic>Laboratories</topic><topic>Medical tests</topic><topic>Metronidazole</topic><topic>Original Research</topic><topic>Pain</topic><topic>Patients</topic><topic>Surveillance</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stokely, Janelle N</creatorcontrib><creatorcontrib>Niendorf, Sandra</creatorcontrib><creatorcontrib>Taube, Stefan</creatorcontrib><creatorcontrib>Hoehne, Marina</creatorcontrib><creatorcontrib>Young, Vincent B</creatorcontrib><creatorcontrib>Rogers, Mary Am</creatorcontrib><creatorcontrib>Wobus, Christiane E</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stokely, Janelle N</au><au>Niendorf, Sandra</au><au>Taube, Stefan</au><au>Hoehne, Marina</au><au>Young, Vincent B</au><au>Rogers, Mary Am</au><au>Wobus, Christiane E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of human norovirus and Clostridium difficile coinfections in adult hospitalized patients</atitle><jtitle>Clinical epidemiology</jtitle><addtitle>Clin Epidemiol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>8</volume><spage>253</spage><epage>260</epage><pages>253-260</pages><issn>1179-1349</issn><eissn>1179-1349</eissn><abstract>Human norovirus (HuNoV) and Clostridium difficile are common causes of infectious gastroenteritis in adults in the US. However, limited information is available regarding HuNoV and C. difficile coinfections. Our study was designed to evaluate the prevalence of HuNoV and C. difficile coinfections among adult patients in a hospital setting and disease symptomatology.
For a cross-sectional analysis, 384 fecal samples were tested for the presence of C. difficile toxins from patients (n=290), whom the provider suspected of C. difficile infections. Subsequent testing was then performed for HuNoV genogroups I and II. Multinomial logistic regression was performed to determine symptoms more frequently associated with coinfections.
The final cohort consisted of the following outcome groups: C. difficile (n=196), C. difficile + HuNoV coinfection (n=40), HuNoV only (n=12), and neither (n=136). Coinfected patients were more likely to develop nausea, gas, and abdominal pain and were more likely to seek treatment in the winter season compared with individuals not infected or infected with either pathogen alone.
Our study revealed that patients with coinfection are more likely to experience certain gastrointestinal symptoms, in particular abdominal pain, suggesting an increased severity of disease symptomatology in coinfected patients.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>27418856</pmid><doi>10.2147/CLEP.S106495</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical epidemiology, 2016-01, Vol.8, p.253-260 |
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| source | Taylor & Francis Open Access; Publicly Available Content Database; PubMed Central |
| subjects | Abdomen Adults Age Anopheles Antibiotics Antigens Clinical medicine Diarrhea Disease control Epidemiology Gastroenteritis Hospital patients Hospitalization Infection Infections Infectious diseases Internal medicine Laboratories Medical tests Metronidazole Original Research Pain Patients Surveillance Vomiting |
| title | Prevalence of human norovirus and Clostridium difficile coinfections in adult hospitalized patients |
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