Pregnancy outcomes in cystic fibrosis: a 10-year experience from a UK centre

• Published in: Obstetric medicine 2015-06, Vol.8 (2), p.99-101
• Main Authors: Renton, M, Priestley, L, Bennett, L, Mackillop, L, Chapman, SJ
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 1753-495X; 1753-4968
• DOI: 10.1177/1753495X15575628

Background Cystic fibrosis manifests as a multisystem disease, despite this female fertility is relatively preserved with levels approaching that of the non-cystic fibrosis population. We reviewed pregnancies in cystic fibrosis patients over a 10-year period from a UK adult cystic fibrosis centre by considering maternal and fetal outcomes. Methods We conducted a retrospective case-note review of pregnancies during 2003–2013 using respiratory and obstetric records. Results We observed moderate falls in lung function immediately after delivery, which persisted at 12 months postpartum. We found that a decline in lung function at delivery was a marker for further decline in function during the subsequent postpartum period. We found baseline lung function was predictive of gestational age at delivery. We observed a high incidence of haemoptysis. Conclusion Consistent with current guidance we found pregnancy is feasible and well tolerated in the majority of patients with cystic fibrosis. There was a high incidence of haemoptysis, which warrants further study.