The Road to Reproducibility in Animal Research

ABSTRACT Reproducibility of research findings is the hallmark of scientific advance. However, the recently noted lack of reproducibility and transparency of published research using animal models of human biology and disease has alarmed funders, scientists, and the public. Improved reporting of meth...

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Bibliographic Details
Published in:Journal of bone and mineral research 2016-07, Vol.31 (7), p.1317-1319
Main Author: Jilka, Robert L
Format: Article
Language:English
Subjects:
ANIMAL MODELS
Animals
Biomedical Research
Disease Models, Animal
Guidelines as Topic
PRACTICE/POLICY‐RELATED ISSUES
PRECLINICAL STUDIES
Reproducibility of Results
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Summary:ABSTRACT Reproducibility of research findings is the hallmark of scientific advance. However, the recently noted lack of reproducibility and transparency of published research using animal models of human biology and disease has alarmed funders, scientists, and the public. Improved reporting of methodology and better use of statistical tools are needed to enhance the quality and utility of published research. Reporting guidelines like Animal Research: Reporting In Vivo Experiments (ARRIVE) have been devised to achieve these goals, but most biomedical research journals, including the JBMR, have not been able to obtain high compliance. Cooperative efforts among authors, reviewers and editors—empowered by increased awareness of their responsibilities, and enabled by user‐friendly guidelines—are needed to solve this problem. © 2016 American Society for Bone and Mineral Research.
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.2881