Calcium-permeable ion channels in the kidney

Calcium ions (Ca(2+)) are crucial for a variety of cellular functions. The extracellular and intracellular Ca(2+) concentrations are thus tightly regulated to maintain Ca(2+) homeostasis. The kidney, one of the major organs of the excretory system, regulates Ca(2+) homeostasis by filtration and reab...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2016-06, Vol.310 (11), p.F1157-F1167
Main Authors: Zhou, Yiming, Greka, Anna
Format: Article
Language:English
Subjects:
Animals
Calcium
Calcium - metabolism
Calcium Channels - metabolism
Calcium Signaling - physiology
Homeostasis
Humans
Kidney - metabolism
Kidney diseases
Kidney Diseases - metabolism
Nephrology
Permeability
Physiology
Reviews
Signal transduction
Transient Receptor Potential Channels - metabolism
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Summary:Calcium ions (Ca(2+)) are crucial for a variety of cellular functions. The extracellular and intracellular Ca(2+) concentrations are thus tightly regulated to maintain Ca(2+) homeostasis. The kidney, one of the major organs of the excretory system, regulates Ca(2+) homeostasis by filtration and reabsorption. Approximately 60% of the Ca(2+) in plasma is filtered, and 99% of that is reabsorbed by the kidney tubules. Ca(2+) is also a critical signaling molecule in kidney development, in all kidney cellular functions, and in the emergence of kidney diseases. Recently, studies using genetic and molecular biological approaches have identified several Ca(2+)-permeable ion channel families as important regulators of Ca(2+) homeostasis in kidney. These ion channel families include transient receptor potential channels (TRP), voltage-gated calcium channels, and others. In this review, we provide a brief and systematic summary of the expression, function, and pathological contribution for each of these Ca(2+)-permeable ion channels. Moreover, we discuss their potential as future therapeutic targets.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00117.2016