Background-based Delineation of Internal Tumor Volume in Static Positron Emission Tomography in a Phantom Study

Objective(s): Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm. Methods: Three hollow models were filled with 55.0 kBq/mL fluorin...

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Bibliographic Details
Published in:Asia oceania journal of nuclear medicine and biology 2016-01, Vol.4 (1), p.38-44
Main Authors: Chen Yangchun, Chen, Xiangrong, Ji-an, Liu, Li Fanyong
Format: Article
Language:English
Subjects:
Neoplasia
Original
Positron emission tomography
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Summary:Objective(s): Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm. Methods: Three hollow models were filled with 55.0 kBq/mL fluorine-18 fluorodeoxyglucose (18F-FDG) to represent tumors. The models were fixed to a barrel filled with 5.9 kBq/mL 18F-FDG to characterize normal lung tissues as a phantom. The PET/CT images of the phantom were acquired at rest. Then, the barrel was moved periodically to simulate breathing while acquiring PET/CT data. Volume recovery coefficient (VRC) was applied to evaluate the accuracy of ITVs. For statistical analysis, paired t-test and analysis of variance were applied. Results: The VRCs ranged from 0.74 to 0.98 and significantly varied among gross tumor volumes for delineating ITV (P0.05), whereas VRC decreased with increasing distance in three-dimensional PET scans (P
ISSN:2322-5718
2322-5726
DOI:10.7508/aojnmb.2016.04.006