Increased risk of osteoporosis in patients with erectile dysfunction: A nationwide population-based cohort study

In this study, we aimed to investigate the risk of osteoporosis in patients with erectile dysfunction (ED) by analyzing data from the Taiwan National Health Insurance Research Database (NHIRD). From the Taiwan NHIRD, we analyzed data on 4460 patients aged ≥40 years diagnosed with ED between 1996 and...

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Bibliographic Details
Published in:Medicine (Baltimore) 2016-06, Vol.95 (26), p.e4024-e4024
Main Authors: Wu, Chieh-Hsin, Lu, Ying-Yi, Chai, Chee-Yin, Su, Yu-Feng, Tsai, Tai-Hsin, Tsai, Feng-Ji, Lin, Chih-Lung
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cohort Studies
Erectile Dysfunction - complications
Humans
Male
Middle Aged
Observational Study
Osteoporosis - complications
Osteoporosis - epidemiology
Retrospective Studies
Risk Assessment
Taiwan
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Summary:In this study, we aimed to investigate the risk of osteoporosis in patients with erectile dysfunction (ED) by analyzing data from the Taiwan National Health Insurance Research Database (NHIRD). From the Taiwan NHIRD, we analyzed data on 4460 patients aged ≥40 years diagnosed with ED between 1996 and 2010. In total, 17,480 age-matched patients without ED in a 1:4 ratio were randomly selected as the non-ED group. The relationship between ED and the risk of osteoporosis was estimated using Cox proportional hazard regression models. During the follow-up period, 264 patients with ED (5.92%) and 651 patients without ED (3.65%) developed osteoporosis. The overall incidence of osteoporosis was 3.04-fold higher in the ED group than in the non-ED group (9.74 vs 2.47 per 1000 person-years) after controlling for covariates. Compared with patients without ED, patients with psychogenic and organic ED were 3.19- and 3.03-fold more likely to develop osteoporosis. Our results indicate that patients with a history of ED, particularly younger men, had a high risk of osteoporosis. Patients with ED should be examined for bone mineral density, and men with osteoporosis should be evaluated for ED.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000004024