Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder

Highlights • Depressed patients performed below normative standards on tasks of psychomotor speed. • Peripheral inflammatory markers predicted psychomotor speed in depressed patients. • IL-6 and MCP-1 were consistently associated with decreased psychomotor speed. • Psychomotor speed may represent a...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.281-288
Main Authors: Goldsmith, David R, Haroon, Ebrahim, Woolwine, Bobbi J, Jung, Moon Y, Wommack, Evanthia C, Harvey, Philip D, Treadway, Michael T, Felger, Jennifer C, Miller, Andrew H
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Chemokine CCL2 - blood
Chemokines
Cognition
Cytokines
Cytokines - blood
Depression
Depressive Disorder, Major - blood
Depressive Disorder, Major - physiopathology
Female
Humans
Inflammation
Inflammation - blood
Interleukin-6 - blood
Male
Middle Aged
Psychiatry
Psychomotor Performance - physiology
Psychomotor speed
Young Adult
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Summary:Highlights • Depressed patients performed below normative standards on tasks of psychomotor speed. • Peripheral inflammatory markers predicted psychomotor speed in depressed patients. • IL-6 and MCP-1 were consistently associated with decreased psychomotor speed. • Psychomotor speed may represent a target for anti-inflammatory therapy in depression.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.03.025