High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice1

Excess calorie consumption, particularly of a diet high in fat, is a risk factor for both obesity and reproductive disorders. Animal model studies indicate that elevated dietary fat can influence some reproductive functions independent of obesity. In the current study we sought to determine whether...

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Bibliographic Details
Published in:Biology of reproduction 2016-05, Vol.94 (5)
Main Authors: Skaznik-Wikiel, Malgorzata E, Swindle, Delaney C, Allshouse, Amanda A, Polotsky, Alex J, McManaman, James L
Format: Article
Language:English
Subjects:
fertility
high-fat diet
inflammation
ovary
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Summary:Excess calorie consumption, particularly of a diet high in fat, is a risk factor for both obesity and reproductive disorders. Animal model studies indicate that elevated dietary fat can influence some reproductive functions independent of obesity. In the current study we sought to determine whether a high-fat diet (HFD) impacts ovarian function, long-term fertility, and local and systemic markers of inflammation independent of obesity. Five-week-old mice were fed either low-fat diet (control group-LF-Ln) or HFD for 10 wk and were divided based on body weight into high-fat obese (HF-Ob: >25 g) and high-fat lean (HF-Ln:
ISSN:0006-3363
1529-7268
DOI:10.1095/biolreprod.115.137414