Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer

The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer. ANX...

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Bibliographic Details
Published in:BMC cancer 2016-07, Vol.16 (1), p.448-448, Article 448
Main Authors: Choi, Chel Hun, Chung, Joon-Yong, Chung, Eun Joo, Sears, John D, Lee, Jeong-Won, Bae, Duk-Soo, Hewitt, Stephen M
Format: Article
Language:English
Subjects:
Adult
Analysis
Annexin A2 - metabolism
Annexin A4 - metabolism
Biomarkers, Tumor - metabolism
Carcinoma, Adenosquamous - mortality
Carcinoma, Adenosquamous - pathology
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Care and treatment
Cervical cancer
Complications and side effects
Disease-Free Survival
Female
Gene expression
Humans
Immunohistochemistry
Metastasis
Middle Aged
Prognosis
Risk factors
Survival Analysis
Tissue Array Analysis
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
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Summary:The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer. ANXA2 and ANXA4 immunohistochemical staining were performed on a cervical cancer tissue microarray consisting of 46 normal cervical epithelium samples and 336 cervical cancer cases and compared the data with clinicopathological variables, including the survival of cervical cancer patients. ANXA2 expression was lower in cancer tissue (p = 0.002), whereas ANXA4 staining increased significantly in cancer tissues (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-016-2459-y