A tool for mass-screening of paragonimiasis: an enzyme-linked immunosorbent assay with urine samples

Paragonimiasis is one of the foodborn trematodiases and number of the patients was estimated to be about 23 million around the world. To obtain good compliance of people for the surveillance of paragonimiasis, an enzyme-linked immunosorbent assay (ELISA) for the diagnosis of paragonimiasis with unco...

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Bibliographic Details
Published in:Tropical medicine and health 2016-06, Vol.44 (1), p.19-19, Article 19
Main Authors: Qiu, Xu Guang, Nakamura-Uchiyama, Fukumi, Nawa, Yukifumi, Itoh, Makoto
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Enzymes
Infections
Laboratories
Parasites
Parasitic diseases
Serology
Tropical diseases
Tuberculosis
Urine
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Summary:Paragonimiasis is one of the foodborn trematodiases and number of the patients was estimated to be about 23 million around the world. To obtain good compliance of people for the surveillance of paragonimiasis, an enzyme-linked immunosorbent assay (ELISA) for the diagnosis of paragonimiasis with unconcentrated urine samples was developed. Paragonimus westermani antigen specific IgG and IgG4 were detected in urine samples from paragonimiasis patients and the levels correlated well with those detected in the paired serum samples. Cross-reactions observed among other trematodiasis and a tuberculosis patient with the antigen specific IgG were much reduced by detecting the antigen specific IgG4; 9.2 % to 2.3 %. The ELISA with urine samples, which are collected safely and easily, will be a useful tool for a mass-screening of paragonimiasis.
ISSN:1348-8945
1349-4147
1349-4147
DOI:10.1186/s41182-016-0019-4