One ring to rule them all: Current trends in combating bacterial resistance to the β‐lactams

From humble beginnings of a contaminated petri dish, β‐lactam antibiotics have distinguished themselves among some of the most powerful drugs in human history. The devastating effects of antibiotic resistance have nevertheless led to an “arms race” with disquieting prospects. The emergence of multid...

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Bibliographic Details
Published in:Protein science 2016-04, Vol.25 (4), p.787-803
Main Authors: King, Dustin T., Sobhanifar, Solmaz, Strynadka, Natalie C. J.
Format: Article
Language:English
Subjects:
Amides
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Antibiotics
Bacteria
beta-Lactam Resistance - drug effects
beta-Lactamase Inhibitors - chemistry
beta-Lactamase Inhibitors - pharmacology
Humans
Innovations
Multidrug resistance
multidrug resistant bacteria
Multidrug resistant organisms
Penicillin
penicillin‐binding protein
resistance
Reviews
Structure-Activity Relationship
β‐lactam
β‐lactamase
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Summary:From humble beginnings of a contaminated petri dish, β‐lactam antibiotics have distinguished themselves among some of the most powerful drugs in human history. The devastating effects of antibiotic resistance have nevertheless led to an “arms race” with disquieting prospects. The emergence of multidrug resistant bacteria threatens an ever‐dwindling antibiotic arsenal, calling for new discovery, rediscovery, and innovation in β‐lactam research. Here the current state of β‐lactam antibiotics from a structural perspective was reviewed.
ISSN:0961-8368
1469-896X
DOI:10.1002/pro.2889