Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prola...

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Bibliographic Details
Published in:BMC genomics 2016-06, Vol.17 Suppl 3 (Suppl 3), p.436-436, Article 436
Main Authors: Staley, Lyndsay A, Ebbert, Mark T W, Parker, Sheradyn, Bailey, Matthew, Ridge, Perry G, Goate, Alison M, Kauwe, John S K
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alzheimer Disease - blood
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - genetics
Biomarkers - blood
Biomarkers - cerebrospinal fluid
Blood plasma
Calcium-Calmodulin-Dependent Protein Kinases - genetics
Cerebrospinal fluid
Female
Gene expression
Gene Frequency
Genetic aspects
Genome-Wide Association Study - methods
Genotype
Humans
Intracellular Signaling Peptides and Proteins - genetics
Linear Models
Linkage Disequilibrium
Meta-Analysis as Topic
Middle Aged
Polymorphism, Single Nucleotide
Prolactin
Prolactin - blood
Prolactin - cerebrospinal fluid
Sulfotransferases - genetics
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Summary:Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p 
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-016-2785-0