Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos

An expansion of anthropogenic activity around Lagos lagoon, Nigeria, has raised concerns over increasing contaminants entering the lagoon’s ecosystem. The embryotoxicity, teratogenicity and genotoxicity of sediment organic extracts from four sampling zones around Lagos lagoon, Ilaje, Iddo, Atlas Cov...

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Bibliographic Details
Published in:Environmental science and pollution research international 2016-07, Vol.23 (14), p.14489-14501
Main Authors: Sogbanmu, Temitope O., Nagy, Eszter, Phillips, David H., Arlt, Volker M., Otitoloju, Adebayo A., Bury, Nic R.
Format: Article
Language:English
Subjects:
Animals
Anthropogenic factors
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Bioassays
Chemical contaminants
Chemicals
Comet Assay
Contaminants
Contaminated sediments
Danio rerio
DNA Damage
Earth and Environmental Science
Ecosystems
Ecotoxicology
Embryos
Environment
Environmental Chemistry
Environmental Health
Environmental science
Genotoxicity
Geologic Sediments - chemistry
Lagoons
Life sciences
Naphthalene
Nigeria
Organic contaminants
Phenanthrene
Pollutants
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - toxicity
Pyrene
Rainy season
Reagents
Research Article
Sand & gravel
Sediments
Studies
Teratogenicity
Toxicants
Toxicity
Waste Water Technology
Water Management
Water Pollutants, Chemical - analysis
Water Pollution Control
Zebrafish
Zebrafish - embryology
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Summary:An expansion of anthropogenic activity around Lagos lagoon, Nigeria, has raised concerns over increasing contaminants entering the lagoon’s ecosystem. The embryotoxicity, teratogenicity and genotoxicity of sediment organic extracts from four sampling zones around Lagos lagoon, Ilaje, Iddo, Atlas Cove and Apapa, as well as the dominant polycyclic aromatic hydrocarbons (PAHs) identified in water measured during the wet season (naphthalene, phenanthrene, pyrene, benzo[a]pyrene and a mixture of these), were assessed with Danio rerio embryos. Embryos were exposed to varying concentrations of toxicants from 0–72 h post-fertilization (hpf). Embryotoxicity at 72 hpf showed a dose-dependent increase in mortality upon exposure to extracts from all zones, except Atlas Cove. Similarly, higher levels of teratogenic effects, such as increased oedema, and haemorrhage and developmental abnormalities resulted from exposure to extracts from Ilaje, Iddo and Apapa zones. Treatment with single PAHs revealed that significant levels of detrimental effects were obtained only for phenanthrene. The modified comet assay revealed that the oxidative damage to DNA was generally low (
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-016-6490-y