Loading…
Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos
An expansion of anthropogenic activity around Lagos lagoon, Nigeria, has raised concerns over increasing contaminants entering the lagoon’s ecosystem. The embryotoxicity, teratogenicity and genotoxicity of sediment organic extracts from four sampling zones around Lagos lagoon, Ilaje, Iddo, Atlas Cov...
Saved in:
| Published in: | Environmental science and pollution research international 2016-07, Vol.23 (14), p.14489-14501 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c606t-7e9a55122a55638f8c13b8441f46e88450088f5dfee12dc70b819fbf7bd730213 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c606t-7e9a55122a55638f8c13b8441f46e88450088f5dfee12dc70b819fbf7bd730213 |
| container_end_page | 14501 |
| container_issue | 14 |
| container_start_page | 14489 |
| container_title | Environmental science and pollution research international |
| container_volume | 23 |
| creator | Sogbanmu, Temitope O. Nagy, Eszter Phillips, David H. Arlt, Volker M. Otitoloju, Adebayo A. Bury, Nic R. |
| description | An expansion of anthropogenic activity around Lagos lagoon, Nigeria, has raised concerns over increasing contaminants entering the lagoon’s ecosystem. The embryotoxicity, teratogenicity and genotoxicity of sediment organic extracts from four sampling zones around Lagos lagoon, Ilaje, Iddo, Atlas Cove and Apapa, as well as the dominant polycyclic aromatic hydrocarbons (PAHs) identified in water measured during the wet season (naphthalene, phenanthrene, pyrene, benzo[a]pyrene and a mixture of these), were assessed with
Danio rerio
embryos. Embryos were exposed to varying concentrations of toxicants from 0–72 h post-fertilization (hpf). Embryotoxicity at 72 hpf showed a dose-dependent increase in mortality upon exposure to extracts from all zones, except Atlas Cove. Similarly, higher levels of teratogenic effects, such as increased oedema, and haemorrhage and developmental abnormalities resulted from exposure to extracts from Ilaje, Iddo and Apapa zones. Treatment with single PAHs revealed that significant levels of detrimental effects were obtained only for phenanthrene. The modified comet assay revealed that the oxidative damage to DNA was generally low ( |
| doi_str_mv | 10.1007/s11356-016-6490-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4943991</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4318375161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c606t-7e9a55122a55638f8c13b8441f46e88450088f5dfee12dc70b819fbf7bd730213</originalsourceid><addsrcrecordid>eNp1kt2K1TAQx4so7tnVB_BGAt6sYDVp03zcCLKuH3DAG70OaTrpydImx6SVrc_jg5rS47IK3kyGzH9-k8lMUTwj-DXBmL9JhNQNKzFhJaMSl8uDYkcYoSWnUj4sdlhSWpKa0rPiPKUbjCssK_64OKs4ZkJitit-7XUfEhqyDR4l6NwIfkIh9to7g-B2itpMCWnfoWMYFrOYId_rGEY9ZeewdDEYHdvgE3K-mw0gGNu4hCncOvMKTRD1FHpYaSske1sIgbWwop1H73OxgCLEbC9_Qhu1denw8kRKT4pHVg8Jnp7Oi-Lbh-uvV5_K_ZePn6_e7UvDMJtKDlI3DamqbFktrDCkbgWlxFIGQtAGYyFs01kAUnWG41YQaVvL247XuCL1RfF24x7ndoTO5J-IelDH6EYdFxW0U39HvDuoPvxQVNJayhVweQLE8H2GNKnRJQPDoD2EOSkisGCswZxn6Yt_pDdhjj63l1W8lhXNw8oqsqlMDClFsHePIVitO6C2HVB5B9S6A2rJOc_vd3GX8WfoWVBtgpRDvod4r_R_qb8BIhTBwQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1873924209</pqid></control><display><type>article</type><title>Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos</title><source>ABI/INFORM Global</source><source>Springer Nature</source><creator>Sogbanmu, Temitope O. ; Nagy, Eszter ; Phillips, David H. ; Arlt, Volker M. ; Otitoloju, Adebayo A. ; Bury, Nic R.</creator><creatorcontrib>Sogbanmu, Temitope O. ; Nagy, Eszter ; Phillips, David H. ; Arlt, Volker M. ; Otitoloju, Adebayo A. ; Bury, Nic R.</creatorcontrib><description>An expansion of anthropogenic activity around Lagos lagoon, Nigeria, has raised concerns over increasing contaminants entering the lagoon’s ecosystem. The embryotoxicity, teratogenicity and genotoxicity of sediment organic extracts from four sampling zones around Lagos lagoon, Ilaje, Iddo, Atlas Cove and Apapa, as well as the dominant polycyclic aromatic hydrocarbons (PAHs) identified in water measured during the wet season (naphthalene, phenanthrene, pyrene, benzo[a]pyrene and a mixture of these), were assessed with
Danio rerio
embryos. Embryos were exposed to varying concentrations of toxicants from 0–72 h post-fertilization (hpf). Embryotoxicity at 72 hpf showed a dose-dependent increase in mortality upon exposure to extracts from all zones, except Atlas Cove. Similarly, higher levels of teratogenic effects, such as increased oedema, and haemorrhage and developmental abnormalities resulted from exposure to extracts from Ilaje, Iddo and Apapa zones. Treatment with single PAHs revealed that significant levels of detrimental effects were obtained only for phenanthrene. The modified comet assay revealed that the oxidative damage to DNA was generally low (<12 %) overall for all sediment extracts, but was significantly elevated with Ilaje and Iddo sediment extracts when compared with solvent controls. Oxidative damage was observed with the single PAHs, phenanthrene and benzo[a]pyrene, as well as with the PAH mixture. This study highlights that Lagos lagoon sediment extracts have teratogenic, embryotoxic and genotoxic properties, which are likely due to the high molecular weight PAHs present in the extracts, some of which are known or are suspected human carcinogens.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-016-6490-y</identifier><identifier>PMID: 27068906</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Anthropogenic factors ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bioassays ; Chemical contaminants ; Chemicals ; Comet Assay ; Contaminants ; Contaminated sediments ; Danio rerio ; DNA Damage ; Earth and Environmental Science ; Ecosystems ; Ecotoxicology ; Embryos ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Genotoxicity ; Geologic Sediments - chemistry ; Lagoons ; Life sciences ; Naphthalene ; Nigeria ; Organic contaminants ; Phenanthrene ; Pollutants ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - toxicity ; Pyrene ; Rainy season ; Reagents ; Research Article ; Sand & gravel ; Sediments ; Studies ; Teratogenicity ; Toxicants ; Toxicity ; Waste Water Technology ; Water Management ; Water Pollutants, Chemical - analysis ; Water Pollution Control ; Zebrafish ; Zebrafish - embryology</subject><ispartof>Environmental science and pollution research international, 2016-07, Vol.23 (14), p.14489-14501</ispartof><rights>The Author(s) 2016</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-7e9a55122a55638f8c13b8441f46e88450088f5dfee12dc70b819fbf7bd730213</citedby><cites>FETCH-LOGICAL-c606t-7e9a55122a55638f8c13b8441f46e88450088f5dfee12dc70b819fbf7bd730213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1873924209/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1873924209?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,11688,27924,27925,36060,36061,44363,74895</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27068906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sogbanmu, Temitope O.</creatorcontrib><creatorcontrib>Nagy, Eszter</creatorcontrib><creatorcontrib>Phillips, David H.</creatorcontrib><creatorcontrib>Arlt, Volker M.</creatorcontrib><creatorcontrib>Otitoloju, Adebayo A.</creatorcontrib><creatorcontrib>Bury, Nic R.</creatorcontrib><title>Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>An expansion of anthropogenic activity around Lagos lagoon, Nigeria, has raised concerns over increasing contaminants entering the lagoon’s ecosystem. The embryotoxicity, teratogenicity and genotoxicity of sediment organic extracts from four sampling zones around Lagos lagoon, Ilaje, Iddo, Atlas Cove and Apapa, as well as the dominant polycyclic aromatic hydrocarbons (PAHs) identified in water measured during the wet season (naphthalene, phenanthrene, pyrene, benzo[a]pyrene and a mixture of these), were assessed with
Danio rerio
embryos. Embryos were exposed to varying concentrations of toxicants from 0–72 h post-fertilization (hpf). Embryotoxicity at 72 hpf showed a dose-dependent increase in mortality upon exposure to extracts from all zones, except Atlas Cove. Similarly, higher levels of teratogenic effects, such as increased oedema, and haemorrhage and developmental abnormalities resulted from exposure to extracts from Ilaje, Iddo and Apapa zones. Treatment with single PAHs revealed that significant levels of detrimental effects were obtained only for phenanthrene. The modified comet assay revealed that the oxidative damage to DNA was generally low (<12 %) overall for all sediment extracts, but was significantly elevated with Ilaje and Iddo sediment extracts when compared with solvent controls. Oxidative damage was observed with the single PAHs, phenanthrene and benzo[a]pyrene, as well as with the PAH mixture. This study highlights that Lagos lagoon sediment extracts have teratogenic, embryotoxic and genotoxic properties, which are likely due to the high molecular weight PAHs present in the extracts, some of which are known or are suspected human carcinogens.</description><subject>Animals</subject><subject>Anthropogenic factors</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bioassays</subject><subject>Chemical contaminants</subject><subject>Chemicals</subject><subject>Comet Assay</subject><subject>Contaminants</subject><subject>Contaminated sediments</subject><subject>Danio rerio</subject><subject>DNA Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecosystems</subject><subject>Ecotoxicology</subject><subject>Embryos</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Genotoxicity</subject><subject>Geologic Sediments - chemistry</subject><subject>Lagoons</subject><subject>Life sciences</subject><subject>Naphthalene</subject><subject>Nigeria</subject><subject>Organic contaminants</subject><subject>Phenanthrene</subject><subject>Pollutants</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>Pyrene</subject><subject>Rainy season</subject><subject>Reagents</subject><subject>Research Article</subject><subject>Sand & gravel</subject><subject>Sediments</subject><subject>Studies</subject><subject>Teratogenicity</subject><subject>Toxicants</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollution Control</subject><subject>Zebrafish</subject><subject>Zebrafish - embryology</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNp1kt2K1TAQx4so7tnVB_BGAt6sYDVp03zcCLKuH3DAG70OaTrpydImx6SVrc_jg5rS47IK3kyGzH9-k8lMUTwj-DXBmL9JhNQNKzFhJaMSl8uDYkcYoSWnUj4sdlhSWpKa0rPiPKUbjCssK_64OKs4ZkJitit-7XUfEhqyDR4l6NwIfkIh9to7g-B2itpMCWnfoWMYFrOYId_rGEY9ZeewdDEYHdvgE3K-mw0gGNu4hCncOvMKTRD1FHpYaSske1sIgbWwop1H73OxgCLEbC9_Qhu1denw8kRKT4pHVg8Jnp7Oi-Lbh-uvV5_K_ZePn6_e7UvDMJtKDlI3DamqbFktrDCkbgWlxFIGQtAGYyFs01kAUnWG41YQaVvL247XuCL1RfF24x7ndoTO5J-IelDH6EYdFxW0U39HvDuoPvxQVNJayhVweQLE8H2GNKnRJQPDoD2EOSkisGCswZxn6Yt_pDdhjj63l1W8lhXNw8oqsqlMDClFsHePIVitO6C2HVB5B9S6A2rJOc_vd3GX8WfoWVBtgpRDvod4r_R_qb8BIhTBwQ</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Sogbanmu, Temitope O.</creator><creator>Nagy, Eszter</creator><creator>Phillips, David H.</creator><creator>Arlt, Volker M.</creator><creator>Otitoloju, Adebayo A.</creator><creator>Bury, Nic R.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20160701</creationdate><title>Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos</title><author>Sogbanmu, Temitope O. ; Nagy, Eszter ; Phillips, David H. ; Arlt, Volker M. ; Otitoloju, Adebayo A. ; Bury, Nic R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-7e9a55122a55638f8c13b8441f46e88450088f5dfee12dc70b819fbf7bd730213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anthropogenic factors</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bioassays</topic><topic>Chemical contaminants</topic><topic>Chemicals</topic><topic>Comet Assay</topic><topic>Contaminants</topic><topic>Contaminated sediments</topic><topic>Danio rerio</topic><topic>DNA Damage</topic><topic>Earth and Environmental Science</topic><topic>Ecosystems</topic><topic>Ecotoxicology</topic><topic>Embryos</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Genotoxicity</topic><topic>Geologic Sediments - chemistry</topic><topic>Lagoons</topic><topic>Life sciences</topic><topic>Naphthalene</topic><topic>Nigeria</topic><topic>Organic contaminants</topic><topic>Phenanthrene</topic><topic>Pollutants</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>Pyrene</topic><topic>Rainy season</topic><topic>Reagents</topic><topic>Research Article</topic><topic>Sand & gravel</topic><topic>Sediments</topic><topic>Studies</topic><topic>Teratogenicity</topic><topic>Toxicants</topic><topic>Toxicity</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollution Control</topic><topic>Zebrafish</topic><topic>Zebrafish - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sogbanmu, Temitope O.</creatorcontrib><creatorcontrib>Nagy, Eszter</creatorcontrib><creatorcontrib>Phillips, David H.</creatorcontrib><creatorcontrib>Arlt, Volker M.</creatorcontrib><creatorcontrib>Otitoloju, Adebayo A.</creatorcontrib><creatorcontrib>Bury, Nic R.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sogbanmu, Temitope O.</au><au>Nagy, Eszter</au><au>Phillips, David H.</au><au>Arlt, Volker M.</au><au>Otitoloju, Adebayo A.</au><au>Bury, Nic R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>23</volume><issue>14</issue><spage>14489</spage><epage>14501</epage><pages>14489-14501</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>An expansion of anthropogenic activity around Lagos lagoon, Nigeria, has raised concerns over increasing contaminants entering the lagoon’s ecosystem. The embryotoxicity, teratogenicity and genotoxicity of sediment organic extracts from four sampling zones around Lagos lagoon, Ilaje, Iddo, Atlas Cove and Apapa, as well as the dominant polycyclic aromatic hydrocarbons (PAHs) identified in water measured during the wet season (naphthalene, phenanthrene, pyrene, benzo[a]pyrene and a mixture of these), were assessed with
Danio rerio
embryos. Embryos were exposed to varying concentrations of toxicants from 0–72 h post-fertilization (hpf). Embryotoxicity at 72 hpf showed a dose-dependent increase in mortality upon exposure to extracts from all zones, except Atlas Cove. Similarly, higher levels of teratogenic effects, such as increased oedema, and haemorrhage and developmental abnormalities resulted from exposure to extracts from Ilaje, Iddo and Apapa zones. Treatment with single PAHs revealed that significant levels of detrimental effects were obtained only for phenanthrene. The modified comet assay revealed that the oxidative damage to DNA was generally low (<12 %) overall for all sediment extracts, but was significantly elevated with Ilaje and Iddo sediment extracts when compared with solvent controls. Oxidative damage was observed with the single PAHs, phenanthrene and benzo[a]pyrene, as well as with the PAH mixture. This study highlights that Lagos lagoon sediment extracts have teratogenic, embryotoxic and genotoxic properties, which are likely due to the high molecular weight PAHs present in the extracts, some of which are known or are suspected human carcinogens.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27068906</pmid><doi>10.1007/s11356-016-6490-y</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2016-07, Vol.23 (14), p.14489-14501 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4943991 |
| source | ABI/INFORM Global; Springer Nature |
| subjects | Animals Anthropogenic factors Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bioassays Chemical contaminants Chemicals Comet Assay Contaminants Contaminated sediments Danio rerio DNA Damage Earth and Environmental Science Ecosystems Ecotoxicology Embryos Environment Environmental Chemistry Environmental Health Environmental science Genotoxicity Geologic Sediments - chemistry Lagoons Life sciences Naphthalene Nigeria Organic contaminants Phenanthrene Pollutants Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - toxicity Pyrene Rainy season Reagents Research Article Sand & gravel Sediments Studies Teratogenicity Toxicants Toxicity Waste Water Technology Water Management Water Pollutants, Chemical - analysis Water Pollution Control Zebrafish Zebrafish - embryology |
| title | Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T03%3A04%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lagos%20lagoon%20sediment%20organic%20extracts%20and%20polycyclic%20aromatic%20hydrocarbons%20induce%20embryotoxic,%20teratogenic%20and%20genotoxic%20effects%20in%20Danio%20rerio%20(zebrafish)%20embryos&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Sogbanmu,%20Temitope%20O.&rft.date=2016-07-01&rft.volume=23&rft.issue=14&rft.spage=14489&rft.epage=14501&rft.pages=14489-14501&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-016-6490-y&rft_dat=%3Cproquest_pubme%3E4318375161%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c606t-7e9a55122a55638f8c13b8441f46e88450088f5dfee12dc70b819fbf7bd730213%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1873924209&rft_id=info:pmid/27068906&rfr_iscdi=true |