Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network

High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30 % sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associ...

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Bibliographic Details
Published in:Journal of structural and functional genomics 2014-12, Vol.15 (4), p.209-214
Main Authors: Pulavarti, Surya V. S. R. K., Huang, Yuanpeng J., Pederson, Kari, Acton, Thomas B., Xiao, Rong, Everett, John K., Prestegard, James H., Montelione, Gaetano T., Szyperski, Thomas
Format: Article
Language:English
Subjects:
Adapter proteins
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Cancer
Consortia
Cytoskeletal Proteins - chemistry
Forestry Management
Genomics
Human Genetics
Humans
Immunoglobulins
Kinases
Life Sciences
Microbial Genetics and Genomics
Molecular biology
Mutation
Neoplasm Proteins - chemistry
Neoplasms - chemistry
Nuclear Magnetic Resonance, Biomolecular
Plant Genetics and Genomics
Protein Structure, Tertiary
Software
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Summary:High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30 % sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein–protein interactions.
ISSN:1345-711X
1570-0267
DOI:10.1007/s10969-014-9185-y