Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM)

Purpose To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). Materials and Methods The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced‐with...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2016-08, Vol.44 (2), p.426-432
Main Authors: Zhang, Yan, Gauthier, Susan A., Gupta, Ajay, Comunale, Joseph, Chia-Yi Chiang, Gloria, Zhou, Dong, Chen, Weiwei, Giambrone, Ashley E., Zhu, Wenzhen, Wang, Yi
Format: Article
Language:English
Subjects:
Adult
Aging - pathology
Algorithms
Biomarkers
Brain - diagnostic imaging
Brain - pathology
Disease Progression
Early Diagnosis
Female
gadolinium enhancement
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Lesions
longitudinal change
Longitudinal Studies
Magnetic Fields
Magnetic permeability
Magnetic resonance imaging
Magnetic susceptibility
Male
Mapping
Mathematical models
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
NMR
Nuclear magnetic resonance
quantitative susceptibility mapping (QSM)
Reproducibility of Results
Sensitivity and Specificity
Substantia alba
Subtraction Technique
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Summary:Purpose To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). Materials and Methods The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced‐with‐Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow‐up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t‐test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change. Results Lesion susceptibility values relative to normal‐appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced‐with‐Gd at the baseline MRI to 20.42 ± 10.23 ppb when not‐enhanced‐with‐Gd at the follow‐up MRI (P < 0.001). Conclusion MS lesion susceptibility value increases significantly as the lesion evolves from enhanced‐with‐Gd to not‐enhanced‐with‐Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426–432.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.25144