Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects

Platelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support t...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1974-05, Vol.37 (5), p.593-597
Main Authors: Hilton, Barbara P., Zilkha, K. J.
Format: Article
Language:English
Subjects:
Blood Platelets - analysis
Cerebral Arteries - drug effects
Ergotamine - therapeutic use
Humans
Methysergide - therapeutic use
Migraine Disorders - blood
Migraine Disorders - drug therapy
Platelet Adhesiveness - drug effects
Receptors, Drug
Serotonin - blood
Vasoconstrictor Agents - therapeutic use
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Summary:Platelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support the hypothesis that methysergide and ergotamine act by occupying 5-HT uptake sites in vessel walls, leaving 5-HT molecules available to occupy receptors concerned with vasoconstriction.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.37.5.593