Prospective assessment of neurodevelopment in children following a pregnancy complicated by severe pre-eclampsia

ObjectiveTo prospectively examine whether children of women with a pregnancy affected by severe pre-eclampsia (PE), compared to children of women without a PE-affected pregnancy, have differences in neurodevelopmental performance up to 5 years of age.DesignProspective cohort study.SettingTertiary ca...

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Bibliographic Details
Published in:BMJ open 2016-07, Vol.6 (7), p.e010884-e010884
Main Authors: Warshafsky, Chelsie, Pudwell, Jessica, Walker, Mark, Wen, Shi-Wu, Smith, Graeme N
Format: Article
Language:English
Subjects:
Adult
Age
Case-Control Studies
Child, Preschool
Children & youth
Cohort Studies
Diabetes
Female
Health risk assessment
Humans
Hypertension
Infant
Infant, Newborn
Intervention
Longitudinal Studies
Male
Neurodevelopmental Disorders - epidemiology
Obstetrics and Gynaecology
Ontario - epidemiology
Pre-Eclampsia - epidemiology
Preeclampsia
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Prospective Studies
Severity of Illness Index
Studies
Womens health
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Summary:ObjectiveTo prospectively examine whether children of women with a pregnancy affected by severe pre-eclampsia (PE), compared to children of women without a PE-affected pregnancy, have differences in neurodevelopmental performance up to 5 years of age.DesignProspective cohort study.SettingTertiary care centre.ParticipantsWomen were recruited following a PE-affected pregnancy. After each PE participant was recruited, the next normotensive woman without a prior history of PE and matched by parity, maternal age and race was invited to participate. Women with a history of chronic hypertension, diabetes or renal disease were excluded. Total enrolment included 129 PE-affected and 140 normotensive mothers.Outcome measuresThe primary outcome measure was failure of the Ages and Stages Questionnaire (ASQ). The ASQ was completed yearly, until age 5.ResultsA significant difference was found in the proportion of ASQ categories failed in year 3 (p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2015-010884