Subacute brain-stem encephalitis

A 65 year old man developed progressive signs of pontine and medullary dysfunction with striking bilateral paralysis of lateral gaze, dysarthria, dysphagia, and ataxia. A respiratory death occurred seven months from the onset. Pathological examination revealed focal brain-stem changes of perivascula...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1974-07, Vol.37 (7), p.811-816
Main Authors: Waxman, S. G., Sabin, T. D., Embree, L. J.
Format: Article
Language:English
Subjects:
Aged
Ataxia - etiology
Ataxia - pathology
Brain Injuries - complications
Brain Stem - pathology
Encephalitis - complications
Encephalitis - diagnosis
Encephalitis - etiology
Encephalitis - pathology
Gliosis
Humans
Male
Ophthalmoplegia - etiology
Ophthalmoplegia - pathology
Phagocytosis
Respiratory Insufficiency - etiology
Respiratory Insufficiency - pathology
Speech Disorders - etiology
Speech Disorders - pathology
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Summary:A 65 year old man developed progressive signs of pontine and medullary dysfunction with striking bilateral paralysis of lateral gaze, dysarthria, dysphagia, and ataxia. A respiratory death occurred seven months from the onset. Pathological examination revealed focal brain-stem changes of perivascular lymphocytic cuffing, microglial infiltration, glial nodules, and neuronophagia. No underlying malignancy or general disease impairing immunity mechanisms was discovered.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.37.7.811