Diversity of beta-papillomavirus at anogenital and oral anatomic sites of men: The HIM Study

• Published in: Virology (New York, N.Y.) N.Y.), 2016-08, Vol.495, p.33-41
• Main Authors: Nunes, Emily Montosa, Sudenga, Staci L, Gheit, Tarik, Tommasino, Massimo, Baggio, Maria Luiza, Ferreira, Silvaneide, Galan, Lenice, Silva, Roberto C, Pierce Campbell, Christine M, Lazcano-Ponce, Eduardo, Giuliano, Anna R, Villa, Luisa L, Sichero, Laura
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Anal Canal - virology; Anogenital; Betapapillomavirus - classification; Betapapillomavirus - genetics; Brazil - epidemiology; Cutaneous human papillomavirus; DNA, Viral; Female; Genitalia, Male - virology; Genotype; HIM Study; Humans; Infectious Disease; Male; Males; Middle Aged; Mouth - virology; Oral; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Population Surveillance; Prevalence; Risk Factors; Sexual Behavior; United States - epidemiology; Young Adult
• ISSN: 0042-6822; 1096-0341
• DOI: 10.1016/j.virol.2016.04.031

Abstract Our goal was to describe prevalence of β-HPVs at three anatomic sites among 717 men from Brazil, Mexico and US enrolled in the HPV Infection in Men (HIM) Study. β-HPVs were genotyped using Luminex technology. Overall, 77.7%, 54.3% and 29.3% men were positive for any β-HPV at the genitals, anal canal, and oral cavity, respectively. Men from US and Brazil were significantly less likely to have β-HPV at the anal canal than men from Mexico. Older men were more likely to have β-HPV at the anal canal compared to younger men. Prevalence of β-HPV at the oral cavity was significantly associated with country of origin and age. Current smokers were significantly less likely to have β-HPV in the oral cavity than men who never smoked. Lack of associations between β-HPV and sexual behaviors may suggest other routes of contact such as autoinoculation which need to be explored further.