Creating biomaterials with spatially organized functionality

Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to r...

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Published in:Experimental biology and medicine (Maywood, N.J.) N.J.), 2016-05, Vol.241 (10), p.1025-1032
Main Authors: Chow, Lesley W, Fischer, Jacob F
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - isolation & purification
Biocompatible Materials - pharmacology
Chemical Phenomena
Guided Tissue Regeneration - methods
Humans
Minireview
Tissue Engineering - methods
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description Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue’s biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biomaterial to recapitulate native tissue organization and function.
doi_str_mv 10.1177/1535370216648023
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subjects Animals
Biocompatible Materials - chemistry
Biocompatible Materials - isolation & purification
Biocompatible Materials - pharmacology
Chemical Phenomena
Guided Tissue Regeneration - methods
Humans
Minireview
Tissue Engineering - methods
title Creating biomaterials with spatially organized functionality
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