miR-1260b is a Potential Prognostic Biomarker in Colorectal Cancer

BACKGROUND Colorectal cancer (CRC) mainly refers to colon and rectum cancer, which is the most common gastrointestinal malignant tumor. MicroRNAs (miRNAs) in tumors participate in multiple processes of malignancy development, including cell differentiation, proliferation, invasion, and metastasis. I...

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Bibliographic Details
Published in:Medical science monitor 2016-07, Vol.22, p.2417-2423
Main Authors: Liu, Deng-Rui, Guan, Quan-Lin, Gao, Ming-Tai, Jiang, Lei, Kang, Hong-Xia
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Female
Humans
Kaplan-Meier Estimate
Lab/In Vitro Research
Lymphatic Metastasis
Male
MicroRNAs - biosynthesis
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
Multivariate Analysis
Prognosis
Real-Time Polymerase Chain Reaction
Survival Analysis
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Summary:BACKGROUND Colorectal cancer (CRC) mainly refers to colon and rectum cancer, which is the most common gastrointestinal malignant tumor. MicroRNAs (miRNAs) in tumors participate in multiple processes of malignancy development, including cell differentiation, proliferation, invasion, and metastasis. In this study we explored the relationship of miR-1260b abnormal expression with clinical pathological features in CRC patients. MATERIAL AND METHODS The expression of miR-1260b was detected by real-time quantitative polymerase chain reaction (real-time PCR) in 120 cases of CRC tissues. The correlation of miR-1260b expression with the clinicopathologic features of CRC was analyzed by SPSS 21.0 statistical software. The Kaplan-Meier method was used for survival analysis. Cox regression analyses were conducted to determine whether miR-1260b was an independent predictor of survival for CRC patients. RESULTS The miR-1260b expression in CRC was significantly higher than the expression levels in the corresponding para-carcinoma tissues (P
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/msm.898733