Capillary-induced Homogenization of Matrix in Paper: A Powerful Approach for the Quantification of Active Pharmaceutical Ingredients Using Mass Spectrometry Imaging

Herein we present a novel approach for the quantification of active pharmaceutical ingredients (APIs) using mass spectrometry imaging. This strategy uses a filter paper previously “eluted” with a MALDI matrix solution as a support for analyte application. Samples are submitted to mass spectrometry i...

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Bibliographic Details
Published in:Scientific reports 2016-07, Vol.6 (1), p.29970-29970, Article 29970
Main Authors: de Menezes, Maico, de Oliveira, Diogo Noin, Catharino, Rodrigo Ramos
Format: Article
Language:English
Subjects:
639/638/11/296
639/638/224/685
Humanities and Social Sciences
multidisciplinary
Science
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Summary:Herein we present a novel approach for the quantification of active pharmaceutical ingredients (APIs) using mass spectrometry imaging. This strategy uses a filter paper previously “eluted” with a MALDI matrix solution as a support for analyte application. Samples are submitted to mass spectrometry imaging (MSI) and quantification through characteristic fingerprints is ultimately performed. Results for the content of rosuvastatin from a known formulation are comparable to those obtained with a validated HPLC method.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep29970