Y90 Radioembolization in chemo-refractory metastastic, liver dominant colorectal cancer patients: outcome assessment applying a predictive scoring system

In treatment-refractory liver dominant metastatic colorectal cancer, the role of liver directed therapies still is unclear. We sought to determine a prognostic score for Y90 radioembolization in these patients. We analyzed 106 patients with refractory liver dominant mCRC who had undergone a total of...

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Bibliographic Details
Published in:BMC cancer 2016-07, Vol.16 (1), p.509, Article 509
Main Authors: Damm, Robert, Seidensticker, Ricarda, Ulrich, Gerhard, Breier, Leonie, Steffen, Ingo G, Seidensticker, Max, Garlipp, Benjamin, Mohnike, Konrad, Pech, Maciej, Amthauer, Holger, Ricke, Jens
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens
Biomarkers
CA-19-9 Antigen - blood
Cancer
Cancer therapies
Carcinoembryonic Antigen - blood
Care and treatment
Chemotherapy
Colorectal cancer
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Complications and side effects
Drug Resistance, Neoplasm
Embolization, Therapeutic - methods
Female
Health aspects
Humans
Kaplan-Meier Estimate
Karnofsky Performance Status
Liver
Liver - pathology
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Magnetic resonance imaging
Male
Metastasis
Middle Aged
Multivariate Analysis
Neoplasm Metastasis
Outcome Assessment (Health Care) - methods
Outcome Assessment (Health Care) - statistics & numerical data
Patient outcomes
Patients
Prognosis
Proportional Hazards Models
Regression analysis
Risk factors
Yttrium Radioisotopes - therapeutic use
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Summary:In treatment-refractory liver dominant metastatic colorectal cancer, the role of liver directed therapies still is unclear. We sought to determine a prognostic score for Y90 radioembolization in these patients. We analyzed 106 patients with refractory liver dominant mCRC who had undergone a total of 178 Y90 radioembolizations with resin microspheres was collected. Potential factors influencing survival were analyzed using a Cox regression. The Log rank test served to establish prognostic factors and to form a clinical score for outcome prediction after Y90 radioembolization. Median survival of all patients was 6.7 months. Neither age nor prior surgical or systemic therapy nor metastatic spread had an effect on survival. In contrast, hepatic tumor load, Karnofsky index as well as CEA and CA19-9 serums level had a significant influence (p 130 ng/ml or CA19-9 > 200U/ml and Karnofsky index
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-016-2549-x