Go-sha-jinki-Gan (GJG) ameliorates allodynia in chronic constriction injury model mice via suppression of TNF-α expression in the spinal cord

• Published in: Molecular pain 2016, Vol.12
• Main Authors: Nakanishi, Miho, Nakae, Aya, Kishida, Yuki, Baba, Kousuke, Sakashita, Noriko, Shibata, Masahiko, Yoshikawa, Hideki, Hagihara, Keisuke
• Format: Article
• Language: English
• Subjects: Analgesics; Animal models; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cold Temperature; Constriction; Disease Models, Animal; Dorsal horn; Drugs, Chinese Herbal - adverse effects; Drugs, Chinese Herbal - therapeutic use; Herbal medicine; Hyperalgesia; Hyperalgesia - drug therapy; Hyperalgesia - metabolism; Immunohistochemistry; Injections, Spinal; Invasiveness; Male; Mice, Inbred C57BL; Microglia; Microglia - drug effects; Microglia - metabolism; Microglia - pathology; Neuralgia; Pain perception; Phosphorylation; Spinal cord; Spinal Cord - drug effects; Spinal Cord - metabolism; Spinal Cord - pathology; Spinal cord injuries; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α
• ISSN: 1744-8069; 1744-8069
• DOI: 10.1177/1744806916656382

Background Alternative medicine is noted for its clinical effect and minimal invasiveness in the treatment of neuropathic pain. Go-sha-jinki-Gan, a traditional Japanese herbal medicine, has been used for meralgia and numbness in elderly patients. However, the exact mechanism of GJG is unclear. This study aimed to investigate the molecular mechanism of the analgesic effect of GJG in a chronic constriction injury model. Results GJG significantly reduced allodynia and hyperalgesia from the early phase (von Frey test, p