Genotoxicity assessment of two common curing weeds: Hyptis suaveolens (L.) Poir. and Leucas indica (L.) R. Br

Hyptis suaveolens and Leucas indica , two common weeds were selected for the present study, to reveal their probable cytotoxic potential. The meristematic root tips of Allium cepa were used for testing the cytotoxic property of the aqueous leaf extracts containing both polar and non-polar compounds,...

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Bibliographic Details
Published in:Cytotechnology (Dordrecht) 2016-08, Vol.68 (4), p.1513-1527
Main Authors: Sumitha, K. V., Thoppil, J. E.
Format: Article
Language:English
Subjects:
Allium cepa
Apoptosis
Ayurvedic medicine
Biochemistry
Biomedicine
Biotechnology
Bronchitis
Cell division
Cell walls
Chemistry
Chemistry and Materials Science
Cytokinesis
Cytotoxicity
DNA fragmentation
Essential oils
Folk medicine
Genotoxicity
Hyptis suaveolens
Insecticides
Leaves
Leucas
Medical research
Metaphase
Original
Original Article
Pesticides
Plant extracts
Secondary metabolites
Skin
Toxicity
Tropical diseases
Ulcers
Weeds
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Summary:Hyptis suaveolens and Leucas indica , two common weeds were selected for the present study, to reveal their probable cytotoxic potential. The meristematic root tips of Allium cepa were used for testing the cytotoxic property of the aqueous leaf extracts containing both polar and non-polar compounds, and that containing polar compounds alone, at different concentrations (0.125, 0.25, 0.5, 1 and 2 %) and at different time durations, using distilled water as negative control. Mitotic squash preparations were made using a standard protocol. The mitotic index of the treated root tip cells was found to be decreasing and the abnormality percentage was found to be increasing with increase in extract concentration when compared with the control. Maximum cytotoxicity was observed in the extract containing both polar and non-polar compounds. Both the tested plants were found to be cytotoxic. The abnormalities noticed were of both clastogenic (nuclear lesions, nuclear fragmentation, etc.) and non-clastogenic (aberrant cell wall formation at cytokinesis, ball metaphase, etc.) types. Both plant extracts were found to significantly ( P  
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-015-9911-8