Loading…
Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study
Adiponectin is an adipocyte hormone involved in energy homeostasis and metabolism. However, its role in early infancy is poorly understood. We recruited a total of 443 pregnant women and their children in this prospective study. Cord blood samples were successfully obtained from 331 neonates. Matern...
Saved in:
Published in: | BMC pregnancy and childbirth 2016-07, Vol.16 (1), p.189-189, Article 189 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c494t-621ba25c8e24afb103c4200d7e56d252c91cd5bf5aeec7df321e3b89e74926b93 |
---|---|
cites | cdi_FETCH-LOGICAL-c494t-621ba25c8e24afb103c4200d7e56d252c91cd5bf5aeec7df321e3b89e74926b93 |
container_end_page | 189 |
container_issue | 1 |
container_start_page | 189 |
container_title | BMC pregnancy and childbirth |
container_volume | 16 |
creator | Zhang, Zhe-Qing Lu, Qing-Gui Huang, Jie Jiao, Chang-Ya Huang, Shao-Ming Mao, Li-Mei |
description | Adiponectin is an adipocyte hormone involved in energy homeostasis and metabolism. However, its role in early infancy is poorly understood.
We recruited a total of 443 pregnant women and their children in this prospective study. Cord blood samples were successfully obtained from 331 neonates. Maternal and umbilical blood serum adiponectin were measured. The weight-, height- and BMI-for-age Z scores of infants at birth and at 3, 6 and 12 months of age were assessed.
Multiple linear regression analysis indicated that cord blood but not maternal serum adiponectin was positively associated with all of the anthropometric measures at birth (P |
doi_str_mv | 10.1186/s12884-016-0978-9 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4962456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2209761631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-621ba25c8e24afb103c4200d7e56d252c91cd5bf5aeec7df321e3b89e74926b93</originalsourceid><addsrcrecordid>eNpdkc9qFTEUh4MotlYfwI0E3LgZTTL5M3EhSNFWqLjRdcgkZ2xKbjImmQvXJ_CxnfHWUl3lQL7z45zzIfSckteUDvJNpWwYeEeo7IhWQ6cfoFPKFe1Yr_uH9-oT9KTWG0KoGgR5jE6Y4kJrPZyiX59tg5JsxDZ57HLxeIw5e2x9mHMC10LCEfYQK16rAtG2kBNuGc-5ti7ZtvaO2R9wDT9hY0KabGp_8HYNeAqlNnwAW3CecAwTvMUWzyXXeUvfA65t8Yen6NFkY4Vnt-8Z-vbxw9fzy-7qy8Wn8_dXneOat04yOlom3ACM22mkpHecEeIVCOmZYE5T58U4CQvglJ96RqEfBw2KayZH3Z-hd8fceRl34B2kVmw0cwk7Ww4m22D-_Unh2nzPe8O1ZFzINeDVbUDJPxaozexCdRCjTZCXauhAlOiFUGRFX_6H3uRlO3Y1jK3GJJU9XSl6pNx6k1pguhuGErN5NkfPZvVsNs9m2-LF_S3uOv6K7X8DJd6mWA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2209761631</pqid></control><display><type>article</type><title>Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>PubMed Central Free</source><creator>Zhang, Zhe-Qing ; Lu, Qing-Gui ; Huang, Jie ; Jiao, Chang-Ya ; Huang, Shao-Ming ; Mao, Li-Mei</creator><creatorcontrib>Zhang, Zhe-Qing ; Lu, Qing-Gui ; Huang, Jie ; Jiao, Chang-Ya ; Huang, Shao-Ming ; Mao, Li-Mei</creatorcontrib><description>Adiponectin is an adipocyte hormone involved in energy homeostasis and metabolism. However, its role in early infancy is poorly understood.
We recruited a total of 443 pregnant women and their children in this prospective study. Cord blood samples were successfully obtained from 331 neonates. Maternal and umbilical blood serum adiponectin were measured. The weight-, height- and BMI-for-age Z scores of infants at birth and at 3, 6 and 12 months of age were assessed.
Multiple linear regression analysis indicated that cord blood but not maternal serum adiponectin was positively associated with all of the anthropometric measures at birth (P < 0.01). Using Generalized Estimating Equation model after adjustment for sex, time, maternal age, gestational age, prepregnancy BMI, weight gain during pregnancy, maternal education, parity, history of miscarriage and mode of delivery, for every 1-μg/ml increment of maternal serum adiponectin, the height-for-age Z score during the first year of life increased by 0.026 (P =0.013) on average, and the height-for-age Z score of infants in the highest quartile of maternal serum adiponectin was 0.270 (95 % CI: 0.013-0.527) higher than those in the lowest quartile. The changes in weight-for-age Z score from birth decreased by 0.67 × 10(-2) on average with every 1-μg/ml additional increase of cord blood adiponectin (P = 0.047). The infants in the highest quartile of cord blood adiponectin showed a -0.368 (95 % CI, -0.701--0.035) decrease in weight-for-age Z score change from birth compared with those in the lowest quartile.
Cord blood adiponectin concentration is a determinant of infant birth size and weight gain in the first year of life. Circulating maternal adiponectin during pregnancy may predict postnatal height growth.</description><identifier>ISSN: 1471-2393</identifier><identifier>EISSN: 1471-2393</identifier><identifier>DOI: 10.1186/s12884-016-0978-9</identifier><identifier>PMID: 27459998</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Adipocytes ; Adiponectin - blood ; Adult ; Age ; Babies ; Birth weight ; Body Height ; Body Mass Index ; Body Size ; Body Weight ; Diabetes ; Ethnicity ; Female ; Fetal Blood - chemistry ; Gestational Age ; Health risk assessment ; Humans ; Infant ; Infant, Newborn ; Male ; Maternal Serum Screening Tests ; Obesity ; Pregnancy ; Pregnancy Trimesters - blood ; Prospective Studies ; Womens health</subject><ispartof>BMC pregnancy and childbirth, 2016-07, Vol.16 (1), p.189-189, Article 189</ispartof><rights>2016. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-621ba25c8e24afb103c4200d7e56d252c91cd5bf5aeec7df321e3b89e74926b93</citedby><cites>FETCH-LOGICAL-c494t-621ba25c8e24afb103c4200d7e56d252c91cd5bf5aeec7df321e3b89e74926b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962456/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2209761631?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27459998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhe-Qing</creatorcontrib><creatorcontrib>Lu, Qing-Gui</creatorcontrib><creatorcontrib>Huang, Jie</creatorcontrib><creatorcontrib>Jiao, Chang-Ya</creatorcontrib><creatorcontrib>Huang, Shao-Ming</creatorcontrib><creatorcontrib>Mao, Li-Mei</creatorcontrib><title>Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study</title><title>BMC pregnancy and childbirth</title><addtitle>BMC Pregnancy Childbirth</addtitle><description>Adiponectin is an adipocyte hormone involved in energy homeostasis and metabolism. However, its role in early infancy is poorly understood.
We recruited a total of 443 pregnant women and their children in this prospective study. Cord blood samples were successfully obtained from 331 neonates. Maternal and umbilical blood serum adiponectin were measured. The weight-, height- and BMI-for-age Z scores of infants at birth and at 3, 6 and 12 months of age were assessed.
Multiple linear regression analysis indicated that cord blood but not maternal serum adiponectin was positively associated with all of the anthropometric measures at birth (P < 0.01). Using Generalized Estimating Equation model after adjustment for sex, time, maternal age, gestational age, prepregnancy BMI, weight gain during pregnancy, maternal education, parity, history of miscarriage and mode of delivery, for every 1-μg/ml increment of maternal serum adiponectin, the height-for-age Z score during the first year of life increased by 0.026 (P =0.013) on average, and the height-for-age Z score of infants in the highest quartile of maternal serum adiponectin was 0.270 (95 % CI: 0.013-0.527) higher than those in the lowest quartile. The changes in weight-for-age Z score from birth decreased by 0.67 × 10(-2) on average with every 1-μg/ml additional increase of cord blood adiponectin (P = 0.047). The infants in the highest quartile of cord blood adiponectin showed a -0.368 (95 % CI, -0.701--0.035) decrease in weight-for-age Z score change from birth compared with those in the lowest quartile.
Cord blood adiponectin concentration is a determinant of infant birth size and weight gain in the first year of life. Circulating maternal adiponectin during pregnancy may predict postnatal height growth.</description><subject>Adipocytes</subject><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Age</subject><subject>Babies</subject><subject>Birth weight</subject><subject>Body Height</subject><subject>Body Mass Index</subject><subject>Body Size</subject><subject>Body Weight</subject><subject>Diabetes</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Gestational Age</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Maternal Serum Screening Tests</subject><subject>Obesity</subject><subject>Pregnancy</subject><subject>Pregnancy Trimesters - blood</subject><subject>Prospective Studies</subject><subject>Womens health</subject><issn>1471-2393</issn><issn>1471-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkc9qFTEUh4MotlYfwI0E3LgZTTL5M3EhSNFWqLjRdcgkZ2xKbjImmQvXJ_CxnfHWUl3lQL7z45zzIfSckteUDvJNpWwYeEeo7IhWQ6cfoFPKFe1Yr_uH9-oT9KTWG0KoGgR5jE6Y4kJrPZyiX59tg5JsxDZ57HLxeIw5e2x9mHMC10LCEfYQK16rAtG2kBNuGc-5ti7ZtvaO2R9wDT9hY0KabGp_8HYNeAqlNnwAW3CecAwTvMUWzyXXeUvfA65t8Yen6NFkY4Vnt-8Z-vbxw9fzy-7qy8Wn8_dXneOat04yOlom3ACM22mkpHecEeIVCOmZYE5T58U4CQvglJ96RqEfBw2KayZH3Z-hd8fceRl34B2kVmw0cwk7Ww4m22D-_Unh2nzPe8O1ZFzINeDVbUDJPxaozexCdRCjTZCXauhAlOiFUGRFX_6H3uRlO3Y1jK3GJJU9XSl6pNx6k1pguhuGErN5NkfPZvVsNs9m2-LF_S3uOv6K7X8DJd6mWA</recordid><startdate>20160727</startdate><enddate>20160727</enddate><creator>Zhang, Zhe-Qing</creator><creator>Lu, Qing-Gui</creator><creator>Huang, Jie</creator><creator>Jiao, Chang-Ya</creator><creator>Huang, Shao-Ming</creator><creator>Mao, Li-Mei</creator><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160727</creationdate><title>Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study</title><author>Zhang, Zhe-Qing ; Lu, Qing-Gui ; Huang, Jie ; Jiao, Chang-Ya ; Huang, Shao-Ming ; Mao, Li-Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-621ba25c8e24afb103c4200d7e56d252c91cd5bf5aeec7df321e3b89e74926b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adipocytes</topic><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Age</topic><topic>Babies</topic><topic>Birth weight</topic><topic>Body Height</topic><topic>Body Mass Index</topic><topic>Body Size</topic><topic>Body Weight</topic><topic>Diabetes</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Gestational Age</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Maternal Serum Screening Tests</topic><topic>Obesity</topic><topic>Pregnancy</topic><topic>Pregnancy Trimesters - blood</topic><topic>Prospective Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zhe-Qing</creatorcontrib><creatorcontrib>Lu, Qing-Gui</creatorcontrib><creatorcontrib>Huang, Jie</creatorcontrib><creatorcontrib>Jiao, Chang-Ya</creatorcontrib><creatorcontrib>Huang, Shao-Ming</creatorcontrib><creatorcontrib>Mao, Li-Mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Family Health Database (ProQuest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC pregnancy and childbirth</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zhe-Qing</au><au>Lu, Qing-Gui</au><au>Huang, Jie</au><au>Jiao, Chang-Ya</au><au>Huang, Shao-Ming</au><au>Mao, Li-Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study</atitle><jtitle>BMC pregnancy and childbirth</jtitle><addtitle>BMC Pregnancy Childbirth</addtitle><date>2016-07-27</date><risdate>2016</risdate><volume>16</volume><issue>1</issue><spage>189</spage><epage>189</epage><pages>189-189</pages><artnum>189</artnum><issn>1471-2393</issn><eissn>1471-2393</eissn><abstract>Adiponectin is an adipocyte hormone involved in energy homeostasis and metabolism. However, its role in early infancy is poorly understood.
We recruited a total of 443 pregnant women and their children in this prospective study. Cord blood samples were successfully obtained from 331 neonates. Maternal and umbilical blood serum adiponectin were measured. The weight-, height- and BMI-for-age Z scores of infants at birth and at 3, 6 and 12 months of age were assessed.
Multiple linear regression analysis indicated that cord blood but not maternal serum adiponectin was positively associated with all of the anthropometric measures at birth (P < 0.01). Using Generalized Estimating Equation model after adjustment for sex, time, maternal age, gestational age, prepregnancy BMI, weight gain during pregnancy, maternal education, parity, history of miscarriage and mode of delivery, for every 1-μg/ml increment of maternal serum adiponectin, the height-for-age Z score during the first year of life increased by 0.026 (P =0.013) on average, and the height-for-age Z score of infants in the highest quartile of maternal serum adiponectin was 0.270 (95 % CI: 0.013-0.527) higher than those in the lowest quartile. The changes in weight-for-age Z score from birth decreased by 0.67 × 10(-2) on average with every 1-μg/ml additional increase of cord blood adiponectin (P = 0.047). The infants in the highest quartile of cord blood adiponectin showed a -0.368 (95 % CI, -0.701--0.035) decrease in weight-for-age Z score change from birth compared with those in the lowest quartile.
Cord blood adiponectin concentration is a determinant of infant birth size and weight gain in the first year of life. Circulating maternal adiponectin during pregnancy may predict postnatal height growth.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>27459998</pmid><doi>10.1186/s12884-016-0978-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1471-2393 |
ispartof | BMC pregnancy and childbirth, 2016-07, Vol.16 (1), p.189-189, Article 189 |
issn | 1471-2393 1471-2393 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4962456 |
source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central Free |
subjects | Adipocytes Adiponectin - blood Adult Age Babies Birth weight Body Height Body Mass Index Body Size Body Weight Diabetes Ethnicity Female Fetal Blood - chemistry Gestational Age Health risk assessment Humans Infant Infant, Newborn Male Maternal Serum Screening Tests Obesity Pregnancy Pregnancy Trimesters - blood Prospective Studies Womens health |
title | Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T14%3A55%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20and%20cord%20blood%20adiponectin%20levels%20in%20relation%20to%20post-natal%20body%20size%20in%20infants%20in%20the%20first%20year%20of%20life:%20a%20prospective%20study&rft.jtitle=BMC%20pregnancy%20and%20childbirth&rft.au=Zhang,%20Zhe-Qing&rft.date=2016-07-27&rft.volume=16&rft.issue=1&rft.spage=189&rft.epage=189&rft.pages=189-189&rft.artnum=189&rft.issn=1471-2393&rft.eissn=1471-2393&rft_id=info:doi/10.1186/s12884-016-0978-9&rft_dat=%3Cproquest_pubme%3E2209761631%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c494t-621ba25c8e24afb103c4200d7e56d252c91cd5bf5aeec7df321e3b89e74926b93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2209761631&rft_id=info:pmid/27459998&rfr_iscdi=true |