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Electroretinographic detection of human brain dopamine response to oral food stimulation

Objective: The activity of dopamine‐dependent retinal signaling can be assessed using electroretinography. Response of this system to oral food stimulation might provide accessible insight into the brain dopamine response to oral stimuli as retinal dopamine concentration is dependent upon mid brain...

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Published in:Obesity (Silver Spring, Md.) Md.), 2013-05, Vol.21 (5), p.976-980
Main Authors: Nasser, J.A., Parigi, A. Del, Merhige, K., Wolper, C., Geliebter, A., Hashim, S.A.
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container_title Obesity (Silver Spring, Md.)
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creator Nasser, J.A.
Parigi, A. Del
Merhige, K.
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Geliebter, A.
Hashim, S.A.
description Objective: The activity of dopamine‐dependent retinal signaling can be assessed using electroretinography. Response of this system to oral food stimulation might provide accessible insight into the brain dopamine response to oral stimuli as retinal dopamine concentration is dependent upon mid brain dopamine concentration was postulated. Design and Methods: Nine individuals had cone ERG (b wave) response to oral food stimulation and oral methylphenidate (MPH) administration measured on separate days, and completed self reported eating behavior questionnaires. Results: Significant and similar increases in b wave response to both stimuli (P = 0.012 and P = 0.042, MPH and food, respectively) and significant correlations of the food stimulated b wave amplitude with binge eating related behavior as measured by the Gormally Binge Eating Scale (r = 0.68, P = 0.044) and self‐reported trait hunger as measured by the Stunkard and Messick Three Factor Eating Questionnaire (r = 0.67, P = 0.048) were found. Conclusion: The significant increase in food stimulated dopamine dependent b wave amplitude and correlation with methylphenidate stimulated b wave amplitude suggest that ERG may offer a relatively inexpensive and accessible methodology for potentially assess dopaminergic responses to food and other externally applied stimuli that have been implicated in the pathogenesis of a number of human diseases.
doi_str_mv 10.1002/oby.20101
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Results: Significant and similar increases in b wave response to both stimuli (P = 0.012 and P = 0.042, MPH and food, respectively) and significant correlations of the food stimulated b wave amplitude with binge eating related behavior as measured by the Gormally Binge Eating Scale (r = 0.68, P = 0.044) and self‐reported trait hunger as measured by the Stunkard and Messick Three Factor Eating Questionnaire (r = 0.67, P = 0.048) were found. 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ispartof Obesity (Silver Spring, Md.), 2013-05, Vol.21 (5), p.976-980
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source Wiley-Blackwell Read & Publish Collection
subjects Adult
Binge-Eating Disorder - metabolism
Brain - metabolism
Brain research
Bulimia
Disease
Dopamine
Dopamine - metabolism
Dopamine Uptake Inhibitors - pharmacology
Drug dosages
Eating - physiology
Electroretinography - methods
Family medical history
Female
Food
Humans
Hunger
Male
Metabolic disorders
Metabolites
Methylphenidate - pharmacology
Middle Aged
Obesity
Retina
Retina - physiology
Retinal Cone Photoreceptor Cells - drug effects
Retinal Cone Photoreceptor Cells - metabolism
Signal Transduction
Surveys and Questionnaires
Tourette syndrome
title Electroretinographic detection of human brain dopamine response to oral food stimulation
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