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Electroretinographic detection of human brain dopamine response to oral food stimulation
Objective: The activity of dopamine‐dependent retinal signaling can be assessed using electroretinography. Response of this system to oral food stimulation might provide accessible insight into the brain dopamine response to oral stimuli as retinal dopamine concentration is dependent upon mid brain...
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Published in: | Obesity (Silver Spring, Md.) Md.), 2013-05, Vol.21 (5), p.976-980 |
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container_title | Obesity (Silver Spring, Md.) |
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creator | Nasser, J.A. Parigi, A. Del Merhige, K. Wolper, C. Geliebter, A. Hashim, S.A. |
description | Objective:
The activity of dopamine‐dependent retinal signaling can be assessed using electroretinography. Response of this system to oral food stimulation might provide accessible insight into the brain dopamine response to oral stimuli as retinal dopamine concentration is dependent upon mid brain dopamine concentration was postulated.
Design and Methods:
Nine individuals had cone ERG (b wave) response to oral food stimulation and oral methylphenidate (MPH) administration measured on separate days, and completed self reported eating behavior questionnaires.
Results:
Significant and similar increases in b wave response to both stimuli (P = 0.012 and P = 0.042, MPH and food, respectively) and significant correlations of the food stimulated b wave amplitude with binge eating related behavior as measured by the Gormally Binge Eating Scale (r = 0.68, P = 0.044) and self‐reported trait hunger as measured by the Stunkard and Messick Three Factor Eating Questionnaire (r = 0.67, P = 0.048) were found.
Conclusion:
The significant increase in food stimulated dopamine dependent b wave amplitude and correlation with methylphenidate stimulated b wave amplitude suggest that ERG may offer a relatively inexpensive and accessible methodology for potentially assess dopaminergic responses to food and other externally applied stimuli that have been implicated in the pathogenesis of a number of human diseases. |
doi_str_mv | 10.1002/oby.20101 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4964968</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3661780551</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4431-d275443c24fca25f9a91d8e167a3f878820ee5befba881062944f4247fb52f323</originalsourceid><addsrcrecordid>eNp1kU1rFTEUhoMotlYX_gEJuNHFbfM1k2QjaKkfUOhGoa5CZuakN2UmZ0xmlPvvTb31ooIQyCF58vCGl5DnnJ1yxsQZdrtTwTjjD8gxt5JttLTXDw-z4UfkSSm3jKmWNfwxORJSG2WsPSbXFyP0S8YMS0x4k_28jT0dYKmnERPFQLfr5BPtso-JDjj7KSagGcqMqQBdkGL2Iw2IAy1LnNbR3718Sh4FPxZ4dr-fkC_vLz6ff9xcXn34dP72ctMrJflmELqpQy9U6L1ogvWWDwZ4q70MRhsjGEDTQei8MZy1wioVlFA6dI0IUsgT8mbvnddugqGHtNQ4bs5x8nnn0Ef3902KW3eD352ybV2mCl7dCzJ-W6Esboqlh3H0CXAtjkvNWtm0hlX05T_oLa451e-5GlhpYa1uK_V6T_UZS8kQDmE4c3d9udqX-9VXZV_8mf5A_i6oAmd74EccYfd_k7t693Wv_AmmN6DM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1674729976</pqid></control><display><type>article</type><title>Electroretinographic detection of human brain dopamine response to oral food stimulation</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Nasser, J.A. ; Parigi, A. Del ; Merhige, K. ; Wolper, C. ; Geliebter, A. ; Hashim, S.A.</creator><creatorcontrib>Nasser, J.A. ; Parigi, A. Del ; Merhige, K. ; Wolper, C. ; Geliebter, A. ; Hashim, S.A.</creatorcontrib><description>Objective:
The activity of dopamine‐dependent retinal signaling can be assessed using electroretinography. Response of this system to oral food stimulation might provide accessible insight into the brain dopamine response to oral stimuli as retinal dopamine concentration is dependent upon mid brain dopamine concentration was postulated.
Design and Methods:
Nine individuals had cone ERG (b wave) response to oral food stimulation and oral methylphenidate (MPH) administration measured on separate days, and completed self reported eating behavior questionnaires.
Results:
Significant and similar increases in b wave response to both stimuli (P = 0.012 and P = 0.042, MPH and food, respectively) and significant correlations of the food stimulated b wave amplitude with binge eating related behavior as measured by the Gormally Binge Eating Scale (r = 0.68, P = 0.044) and self‐reported trait hunger as measured by the Stunkard and Messick Three Factor Eating Questionnaire (r = 0.67, P = 0.048) were found.
Conclusion:
The significant increase in food stimulated dopamine dependent b wave amplitude and correlation with methylphenidate stimulated b wave amplitude suggest that ERG may offer a relatively inexpensive and accessible methodology for potentially assess dopaminergic responses to food and other externally applied stimuli that have been implicated in the pathogenesis of a number of human diseases.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20101</identifier><identifier>PMID: 23784899</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Binge-Eating Disorder - metabolism ; Brain - metabolism ; Brain research ; Bulimia ; Disease ; Dopamine ; Dopamine - metabolism ; Dopamine Uptake Inhibitors - pharmacology ; Drug dosages ; Eating - physiology ; Electroretinography - methods ; Family medical history ; Female ; Food ; Humans ; Hunger ; Male ; Metabolic disorders ; Metabolites ; Methylphenidate - pharmacology ; Middle Aged ; Obesity ; Retina ; Retina - physiology ; Retinal Cone Photoreceptor Cells - drug effects ; Retinal Cone Photoreceptor Cells - metabolism ; Signal Transduction ; Surveys and Questionnaires ; Tourette syndrome</subject><ispartof>Obesity (Silver Spring, Md.), 2013-05, Vol.21 (5), p.976-980</ispartof><rights>Copyright © 2013 The Obesity Society</rights><rights>Copyright © 2013 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. May 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4431-d275443c24fca25f9a91d8e167a3f878820ee5befba881062944f4247fb52f323</citedby><cites>FETCH-LOGICAL-c4431-d275443c24fca25f9a91d8e167a3f878820ee5befba881062944f4247fb52f323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23784899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasser, J.A.</creatorcontrib><creatorcontrib>Parigi, A. Del</creatorcontrib><creatorcontrib>Merhige, K.</creatorcontrib><creatorcontrib>Wolper, C.</creatorcontrib><creatorcontrib>Geliebter, A.</creatorcontrib><creatorcontrib>Hashim, S.A.</creatorcontrib><title>Electroretinographic detection of human brain dopamine response to oral food stimulation</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective:
The activity of dopamine‐dependent retinal signaling can be assessed using electroretinography. Response of this system to oral food stimulation might provide accessible insight into the brain dopamine response to oral stimuli as retinal dopamine concentration is dependent upon mid brain dopamine concentration was postulated.
Design and Methods:
Nine individuals had cone ERG (b wave) response to oral food stimulation and oral methylphenidate (MPH) administration measured on separate days, and completed self reported eating behavior questionnaires.
Results:
Significant and similar increases in b wave response to both stimuli (P = 0.012 and P = 0.042, MPH and food, respectively) and significant correlations of the food stimulated b wave amplitude with binge eating related behavior as measured by the Gormally Binge Eating Scale (r = 0.68, P = 0.044) and self‐reported trait hunger as measured by the Stunkard and Messick Three Factor Eating Questionnaire (r = 0.67, P = 0.048) were found.
Conclusion:
The significant increase in food stimulated dopamine dependent b wave amplitude and correlation with methylphenidate stimulated b wave amplitude suggest that ERG may offer a relatively inexpensive and accessible methodology for potentially assess dopaminergic responses to food and other externally applied stimuli that have been implicated in the pathogenesis of a number of human diseases.</description><subject>Adult</subject><subject>Binge-Eating Disorder - metabolism</subject><subject>Brain - metabolism</subject><subject>Brain research</subject><subject>Bulimia</subject><subject>Disease</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Uptake Inhibitors - pharmacology</subject><subject>Drug dosages</subject><subject>Eating - physiology</subject><subject>Electroretinography - methods</subject><subject>Family medical history</subject><subject>Female</subject><subject>Food</subject><subject>Humans</subject><subject>Hunger</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Metabolites</subject><subject>Methylphenidate - pharmacology</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Retina</subject><subject>Retina - physiology</subject><subject>Retinal Cone Photoreceptor Cells - drug effects</subject><subject>Retinal Cone Photoreceptor Cells - metabolism</subject><subject>Signal Transduction</subject><subject>Surveys and Questionnaires</subject><subject>Tourette syndrome</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kU1rFTEUhoMotlYX_gEJuNHFbfM1k2QjaKkfUOhGoa5CZuakN2UmZ0xmlPvvTb31ooIQyCF58vCGl5DnnJ1yxsQZdrtTwTjjD8gxt5JttLTXDw-z4UfkSSm3jKmWNfwxORJSG2WsPSbXFyP0S8YMS0x4k_28jT0dYKmnERPFQLfr5BPtso-JDjj7KSagGcqMqQBdkGL2Iw2IAy1LnNbR3718Sh4FPxZ4dr-fkC_vLz6ff9xcXn34dP72ctMrJflmELqpQy9U6L1ogvWWDwZ4q70MRhsjGEDTQei8MZy1wioVlFA6dI0IUsgT8mbvnddugqGHtNQ4bs5x8nnn0Ef3902KW3eD352ybV2mCl7dCzJ-W6Esboqlh3H0CXAtjkvNWtm0hlX05T_oLa451e-5GlhpYa1uK_V6T_UZS8kQDmE4c3d9udqX-9VXZV_8mf5A_i6oAmd74EccYfd_k7t693Wv_AmmN6DM</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Nasser, J.A.</creator><creator>Parigi, A. Del</creator><creator>Merhige, K.</creator><creator>Wolper, C.</creator><creator>Geliebter, A.</creator><creator>Hashim, S.A.</creator><general>John Wiley & Sons, Inc</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201305</creationdate><title>Electroretinographic detection of human brain dopamine response to oral food stimulation</title><author>Nasser, J.A. ; Parigi, A. Del ; Merhige, K. ; Wolper, C. ; Geliebter, A. ; Hashim, S.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-d275443c24fca25f9a91d8e167a3f878820ee5befba881062944f4247fb52f323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Binge-Eating Disorder - metabolism</topic><topic>Brain - metabolism</topic><topic>Brain research</topic><topic>Bulimia</topic><topic>Disease</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Uptake Inhibitors - pharmacology</topic><topic>Drug dosages</topic><topic>Eating - physiology</topic><topic>Electroretinography - methods</topic><topic>Family medical history</topic><topic>Female</topic><topic>Food</topic><topic>Humans</topic><topic>Hunger</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Metabolites</topic><topic>Methylphenidate - pharmacology</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Retina</topic><topic>Retina - physiology</topic><topic>Retinal Cone Photoreceptor Cells - drug effects</topic><topic>Retinal Cone Photoreceptor Cells - metabolism</topic><topic>Signal Transduction</topic><topic>Surveys and Questionnaires</topic><topic>Tourette syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasser, J.A.</creatorcontrib><creatorcontrib>Parigi, A. Del</creatorcontrib><creatorcontrib>Merhige, K.</creatorcontrib><creatorcontrib>Wolper, C.</creatorcontrib><creatorcontrib>Geliebter, A.</creatorcontrib><creatorcontrib>Hashim, S.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasser, J.A.</au><au>Parigi, A. Del</au><au>Merhige, K.</au><au>Wolper, C.</au><au>Geliebter, A.</au><au>Hashim, S.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroretinographic detection of human brain dopamine response to oral food stimulation</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2013-05</date><risdate>2013</risdate><volume>21</volume><issue>5</issue><spage>976</spage><epage>980</epage><pages>976-980</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective:
The activity of dopamine‐dependent retinal signaling can be assessed using electroretinography. Response of this system to oral food stimulation might provide accessible insight into the brain dopamine response to oral stimuli as retinal dopamine concentration is dependent upon mid brain dopamine concentration was postulated.
Design and Methods:
Nine individuals had cone ERG (b wave) response to oral food stimulation and oral methylphenidate (MPH) administration measured on separate days, and completed self reported eating behavior questionnaires.
Results:
Significant and similar increases in b wave response to both stimuli (P = 0.012 and P = 0.042, MPH and food, respectively) and significant correlations of the food stimulated b wave amplitude with binge eating related behavior as measured by the Gormally Binge Eating Scale (r = 0.68, P = 0.044) and self‐reported trait hunger as measured by the Stunkard and Messick Three Factor Eating Questionnaire (r = 0.67, P = 0.048) were found.
Conclusion:
The significant increase in food stimulated dopamine dependent b wave amplitude and correlation with methylphenidate stimulated b wave amplitude suggest that ERG may offer a relatively inexpensive and accessible methodology for potentially assess dopaminergic responses to food and other externally applied stimuli that have been implicated in the pathogenesis of a number of human diseases.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>23784899</pmid><doi>10.1002/oby.20101</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Binge-Eating Disorder - metabolism Brain - metabolism Brain research Bulimia Disease Dopamine Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Drug dosages Eating - physiology Electroretinography - methods Family medical history Female Food Humans Hunger Male Metabolic disorders Metabolites Methylphenidate - pharmacology Middle Aged Obesity Retina Retina - physiology Retinal Cone Photoreceptor Cells - drug effects Retinal Cone Photoreceptor Cells - metabolism Signal Transduction Surveys and Questionnaires Tourette syndrome |
title | Electroretinographic detection of human brain dopamine response to oral food stimulation |
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