Concurrent Chemotherapy of Malignant Glioma in Rats by Using Multidrug-Loaded Biodegradable Nanofibrous Membranes

Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan- and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 gliom...

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Bibliographic Details
Published in:Scientific reports 2016-07, Vol.6 (1), p.30630-30630, Article 30630
Main Authors: Tseng, Yuan-Yun, Huang, Yin-Chen, Yang, Tao-Chieh, Yang, Shun-Tai, Liu, Shou-Cheng, Chang, Tzu-Min, Kau, Yi-Chuan, Liu, Shih-Jung
Format: Article
Language:English
Subjects:
59/57
639/301/357/354
639/925/352/152
692/308/575
692/4028/67/1922
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
Blood Chemical Analysis
Brain Chemistry
Brain Neoplasms - drug therapy
Brain Neoplasms - pathology
Disease Models, Animal
Drug Carriers - administration & dosage
Drug Therapy - methods
Glioblastoma - drug therapy
Glioblastoma - pathology
Humanities and Social Sciences
multidisciplinary
Nanostructures - administration & dosage
Rats
Science
Treatment Outcome
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Summary:Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan- and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 glioma-bearing rats in concurrent and virgin groups, respectively. The concentrations of all applied drugs were significantly higher in the brain than in the blood for more than 8 weeks in all studied rats. Tumor growth was more rapid in the vehicle-treated group and tumor volumes were significantly higher in the vehicle-treated group. Moreover, the average survival time was significantly shorter in the vehicle-treated group ( P  = 0.026) and the BIC/PLGA nanofibrous membranes significantly reduced the risk of mortality ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep30630