Intestinal origin alkaline phosphatase activity in plasma for differential diagnosis of jaundice

Intestinal origin alkaline phosphatase activity (ALP) in plasma was measured by a sensitive immunocapture assay in 104 jaundiced patients--84 with intrahepatic and 20 with post-hepatic jaundice. Increased enzyme activities were observed in those with intrahepatic disease and subnormal values in thos...

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Bibliographic Details
Published in:Journal of clinical pathology 1991-10, Vol.44 (10), p.817-819
Main Authors: Kuwana, T, Rosalki, S B
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Biological and medical sciences
Cholestasis, Extrahepatic - diagnosis
Cholestasis, Extrahepatic - enzymology
Cholestasis, Intrahepatic - diagnosis
Cholestasis, Intrahepatic - enzymology
Diagnosis, Differential
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoassay
Intestines - enzymology
Medical sciences
Sensitivity and Specificity
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Summary:Intestinal origin alkaline phosphatase activity (ALP) in plasma was measured by a sensitive immunocapture assay in 104 jaundiced patients--84 with intrahepatic and 20 with post-hepatic jaundice. Increased enzyme activities were observed in those with intrahepatic disease and subnormal values in those with post-hepatic disease. At a discriminant level intestinal origin ALP showed a diagnostic sensitivity of 77% for intrahepatic cholestasis, with a diagnostic accuracy of 75% for its differentiation from post-hepatic jaundice. This diagnostic accuracy is not as good as that derived with other techniques--for example, imaging--and the technique is therefore not recommended as a supplement or replacement.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.44.10.817