Helicobacter pylori and gastric histamine concentrations

An enzyme isotopic assay was used to determine the histamine concentration in the gastric mucosa of patients positive for Helicobacter pylori with (n = 11) and without duodenal ulceration (n = 9) and in negative controls (n = 7). A significant difference was observed when the histamine content of H...

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Bibliographic Details
Published in:Journal of clinical pathology 1991-07, Vol.44 (7), p.612-613
Main Authors: Queiroz, D M, Mendes, E N, Rocha, G A, Cunha-Melo, J R, Barbosa, A J, Lima, G F, Oliveira, C A
Format: Article
Language:English
Subjects:
Adult
Bacterial diseases
Biological and medical sciences
Biopsy
Duodenal Ulcer - complications
Duodenal Ulcer - metabolism
Female
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Helicobacter Infections - complications
Helicobacter Infections - metabolism
Helicobacter pylori
Histamine - analysis
Humans
Infectious diseases
Male
Medical sciences
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Summary:An enzyme isotopic assay was used to determine the histamine concentration in the gastric mucosa of patients positive for Helicobacter pylori with (n = 11) and without duodenal ulceration (n = 9) and in negative controls (n = 7). A significant difference was observed when the histamine content of H pylori negative subjects was compared with that of positive patients. On the other hand, there was no significant difference in histamine concentration between H pylori positive patients with duodenal ulceration and those without duodenal ulceration. H pylori positive patients with and without duodenal ulceration had significantly lower gastric histamine concentrations than H pylori negative subjects. The lower gastric histamine concentration observed in H pylori positive patients might be due to increased histamine release which could in turn induce increased gastric acid secretion.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.44.7.612