Does Longer Lifespan Mean Longer Healthspan?

Once thought to be impossible, it is now clear that changing the activity of several conserved genetic pathways can lead to lifespan extension in experimental organisms. In humans, however, the goal is to extend healthspan, the functional and disease-free period of life. Are the current pathways to...

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Bibliographic Details
Published in:Trends in cell biology 2016-08, Vol.26 (8), p.565-568
Main Authors: Hansen, Malene, Kennedy, Brian K
Format: Article
Language:English
Subjects:
aging
Animals
Caenorhabditis elegans
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - metabolism
Health
Humans
insulin/IGF-1 signaling
longevity
Longevity - drug effects
Longevity - physiology
Mice
Pathology
Receptor, Insulin - metabolism
Sirolimus - pharmacology
TOR signaling
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Summary:Once thought to be impossible, it is now clear that changing the activity of several conserved genetic pathways can lead to lifespan extension in experimental organisms. In humans, however, the goal is to extend healthspan, the functional and disease-free period of life. Are the current pathways to lifespan extension also improving healthspan?
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2016.05.002