Osteoporosis: The Result of an ‘Aged’ Bone Microenvironment

Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics, cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms and players underlying the pathology of osteoporosis, supporting a model of age-related dysregulation and crosstalk in the bo...

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Bibliographic Details
Published in:Trends in molecular medicine 2016-08, Vol.22 (8), p.641-644
Main Authors: Yu, Bo, Wang, Cun-Yu
Format: Article
Language:English
Subjects:
Adaptive Immunity
Aging
Animals
Bone and Bones - immunology
Bone and Bones - metabolism
Bone and Bones - pathology
Drug Delivery Systems
Drug Discovery
epigenetics
Female
Humans
Male
osteoimmunology
osteoporosis
Osteoporosis - etiology
Osteoporosis - immunology
Osteoporosis - metabolism
Osteoporosis - pathology
Pathology
Wnt signaling
Wnt Signaling Pathway - drug effects
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Summary:Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics, cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms and players underlying the pathology of osteoporosis, supporting a model of age-related dysregulation and crosstalk in the bone microenvironment.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2016.06.002