Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mecha...

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Bibliographic Details
Published in:Trends in cell biology 2016-07, Vol.26 (7), p.486-497
Main Authors: Kai, FuiBoon, Laklai, Hanane, Weaver, Valerie M
Format: Article
Language:English
Subjects:
Animals
Biomechanical Phenomena
cancer
cardiovascular disease
Cell Movement
Disease
Extracellular Matrix - metabolism
extracellular matrix stiffness
fibrosis
Humans
invasion
migration
Neoplasm Invasiveness - pathology
Pathology
Podosomes - pathology
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Summary:Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamellae for cell invasion and migration. Accordingly, deciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing ECM stiffness could ameliorate disease progression.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2016.03.007